Registry for optimal treatment options for mitral valve issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multinational observational study investigates the outcomes of patients with clinically significant mitral insufficiency who underwent transcatheter mitral valve implantation (TMVI) compared to those who were screened for TMVI but deemed ineligible. The study collects and analyzes echocardiography data at baseline and after various interventions, including edge-to-edge repair and surgical options. By examining these outcomes, the study aims to provide insights into the effectiveness of different treatment approaches for mitral regurgitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* clinically significant mitral insufficiency
* patient underwent screening for TMVI
* echocardiography data at baseline (and after TMVI, E2E and surgery)
* follow-up of at least 30 days

Exclusion Criteria:

\- age under 18 years

Where it's running

• Tucson Medical Center
  Tucson, Arizona, United States Recruiting
• Cedars-Sinai Medical Center, Los Angeles
  Los Angeles, California, United States Recruiting
• Tampa General Hospital
  Tampa, Florida, United States Recruiting
• Brigham and Women's Hospital
  Boston, Massachusetts, United States Recruiting
• Minneapolis Heart Institute at Abbott Northwestern Hospital
  Minneapolis, Minnesota, United States Recruiting
• Morristown Medical Center
  Morristown, New Jersey, United States Recruiting

Study contacts

• Principal investigator: Lenard Conradi, MD — University of Cologne
• Study coordinator: Sebastian Ludwig, MD
• Email: se.ludwig@uke.de
• Phone: +494074100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• MITRAL II Pivotal: Transcatheter mitral valve replacement for severe mitral annular calcification

  This trial tests whether placing an Edwards SAPIEN transcatheter valve through a transseptal approach helps high-surgical-risk adults with severe mitral annular calcification and symptomatic mitral valve dysfunction.

  Recruiting at 14 sites Mayo Clinic · Gilbert, Arizona and 16 other locations · NCT04408430

• Mitral Valve Calcification Imaging with TrueVue 3D Light Rendering

  This study tests how well three-dimensional transesophageal echocardiography with TrueVue transillumination detects mitral valve calcifications compared with CT in adults.

  Recruiting Centro Cardiologico Monzino · Milan, Milan · NCT07612553

• Surgical implantation of a polymer prosthetic mitral or aortic valve

  This will test a surgically implanted polymer heart valve to see if it is safe and works well for adults who need mitral or aortic valve replacement.

  Recruiting Mitrassist Lifesciences Limited Co., Ltd. · Shanghai, Shanghai Municipality · NCT07097740

• Abbott Cephea registry for mitral valve disease

  Collects clinical information on adults with symptomatic mitral valve disease to see how correcting the valve with the Cephea system affects outcomes for patients who might be candidates for transcatheter mitral valve replacement.

  Recruiting at 24 sites Abbott Medical Devices · Birmingham, Alabama and 23 other locations · NCT07069673

• Left atrial shunt to help after mitral valve surgery

  This study tests whether making a small opening between the left and right atria during mitral valve repair can relieve high left atrial pressure for adults with primary mitral regurgitation.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06547788

• Observational registry for patients treated with the NeoChord Artificial Chordae System

  This study is looking at how well the NeoChord Artificial Chordae System works for people with degenerative mitral valve disease over five years, without needing any extra procedures beyond regular treatment.

  Recruiting at 5 sites NeoChord · Bonn and 4 other locations · NCT04190602

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.