Condition

Lung Transplantation clinical trials and research

• 13Clinical trials
• 42NIH research projects
• 10Countries

Newest Lung Transplantation clinical trials

All recruiting trials (13)

• Muscle health before and after lung transplant in adults

  This study tests how respiratory and leg muscle health relates to physical function and recovery in adults awaiting and after lung transplantation.

  Recruiting University of Florida · Gainesville, Florida · NCT07747337

• Prediction score for death or lung transplant in emphysema caused by alpha-1 antitrypsin deficiency

  This study tests a new prediction tool to identify people with emphysema due to alpha-1-antitrypsin deficiency who are at high risk of death or needing a lung transplant.

  Recruiting at 4 sites University Hospital, Bordeaux · Bron and 3 other locations · NCT07715617

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Aerobic versus high-intensity interval exercise for people awaiting lung transplant

  This trial tests whether short bursts of high-intensity interval training or longer moderate aerobic sessions better improve walking distance and daily function for people with interstitial lung disease who are on the lung transplant waiting list.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT07065318

• Tacrolimus Melt-Dose® for people after a lung transplant

  This study will test how a once-daily Melt-Dose® tacrolimus (LCPT) is processed in the body and how safe it is for adults who recently had a unilateral or bilateral lung transplant over 12 months.

  Recruiting at 2 sites Chiesi España, S.A.U. · L'Hospitalet de Llobregat, Barcelona and 1 other locations · NCT07042035

• Fostamatinib to see if it’s safe for lung transplant patients with donor-specific antibodies

  This trial tests whether taking fostamatinib is safe for adults who have donor-specific antibodies after a lung transplant.

  Recruiting at 4 sites Phase 1 National Institutes of Health Clinical Center (CC) · Stanford, California and 3 other locations · NCT06948097

• LMWH versus UFH for ECMO anticoagulation during bilateral lung transplant

  This will see if low-molecular-weight heparin (enoxaparin) works as a safe and effective alternative to unfractionated heparin for blood thinning during ECMO around bilateral lung transplantation.

  Recruiting University Hospital, Motol · Prague, Czech Republic · NCT06868823

• CCR5 immune blockade to prevent primary graft dysfunction after lung transplant

  This trial will test whether the drug Maraviroc can prevent primary graft dysfunction in adults undergoing bilateral lung transplantation who have a PGD risk score greater than 50%.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06853223

• Transplanting lungs from donors after circulatory death

  This study is testing a new way to use lungs from donors who have died to see if they can be safely preserved and successfully transplanted into patients who need them.

  Recruiting NYU Langone Health · New York, New York · NCT06327945

• Inhaled LAM-001 for lung transplant patients with bronchiolitis obliterans syndrome

  This study is testing if an inhaled medication called LAM-001 can help lung transplant patients with bronchiolitis obliterans syndrome feel better and improve their lung function.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06018766

• Assessing blood tests for lung transplant rejection

  This study is testing if new blood tests can help doctors better detect lung transplant rejection by comparing them to traditional biopsy methods.

  Recruiting at 17 sites University of Alberta · Phoenix, Arizona and 18 other locations · NCT05837663

• Assessing Diaphragm Activity and Breathing Mechanics During NAVA Ventilation

  This study is testing if a special type of breathing support called NAVA can help lung transplant patients breathe better and protect their lungs while they recover in the ICU.

  Recruiting University of Padova · Padova, Italy · NCT05689476

• Analyzing risk factors for lung transplant complications

  This study is trying to see if certain chemicals in the blood can help predict the risk of serious complications after lung transplants.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT00552357

NIH-funded research (newest 40 of 42)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Body composition and outcomes after lung transplant

  A patient-focused look at how body fat and muscle measurements around the time of lung transplant relate to recovery, complications, and quality of life after surgery.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11585360

• Objective lung-donor quality tools to expand the transplant pool

  A lung-transplant-focused project aims to use gene-based risk tools to better judge donor organs and prevent recipient lung dysfunction.

  NIH research University of Kentucky · Lexington, United States · NIH-11507547

• Bmp-Cx40 signaling to keep lung blood vessels calm after transplant

  A study aims to keep blood vessels in transplanted lungs stable by boosting a specific signaling pathway to reduce injury after transplant.

  NIH research Northwestern University · Chicago, United States · NIH-11459240

• Complement inhibition to protect transplanted lungs from early injury

  A small early trial tests whether a drug that blocks a key part of the immune system can prevent damage to new lungs right after transplant.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11424576

• Phase 1 trial of siltuximab for antibody-mediated rejection after lung transplant

  A early-stage study tests whether siltuximab can help people who have antibody-mediated rejection after lung transplantation.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11419647

• Targeted delivery of immune-suppressing agents to the lung graft to prevent rejection

  A study at Northwestern University will test a new, targeted approach to prevent lung transplant rejection by delivering immune-suppressing drugs directly to the graft while blocking early signals that trigger rejection.

  NIH research Northwestern University · Chicago, United States · NIH-11401866

• Advanced body fat imaging to improve lung transplant outcomes

  This project uses CT imaging of fat distribution to better predict who will do well with a lung transplant and when to list them, with the goal of improving survival after transplant.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11398153

• Integrated mechanisms of primary and chronic graft dysfunction after lung transplantation

  This grant supports research aimed at understanding why some lung transplant patients experience early and long-term graft problems, with the goal of improving survival and quality of life for people who receive a lung transplant.

  NIH research Northwestern University · Chicago, United States · NIH-11394632

• Donor lung CT images to improve predicting severe graft dysfunction after lung transplant

  A study aims to use donor lung CT scans together with clinical information to better predict which patients are at high risk of severe graft dysfunction after lung transplantation.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11394262

• Siltuximab for antibody-mediated rejection after lung transplant

  This trial gives siltuximab to people with antibody-mediated rejection after a lung transplant to try to control the immune response harming the new lung.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11394141

• Immunosuppressive neutrophils in lung transplant recipients

  This grant supports a clinician-scientist in studying how certain white blood cells may help prevent rejection after lung transplant.

  NIH research Washington University · Saint Louis, United States · NIH-11387528

• Body composition and outcomes after lung transplant

  This study explores how body composition affects recovery and patient-reported well-being after lung transplantation.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11386388

• How body fat and muscle affect recovery after lung transplant

  This project looks at how body fat and muscle mass relate to recovery, complications, and quality of life for people getting lung transplants.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11383321

• CCR5 blocker to prevent early lung graft injury after transplant

  A pilot study in people receiving a lung transplant to see if stopping CCR5 with an approved drug called Maraviroc can reduce early graft injury and improve survival.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11378032

• Immunogenomic clues from donor lungs to predict transplant outcomes

  This project looks at how injuries in donor lungs may affect how well a lung transplant works for patients.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11367445

• Optimizing Donor Management in Lung Transplantation for Better Graft Outcomes

  Aimed at improving how brain-dead donor lungs are assessed and managed to increase usable organs for transplantation and improve long-term outcomes for patients.

  NIH research Washington University · Saint Louis, United States · NIH-11353994

• Role of plasma cells in chronic rejection after lung transplantation

  This research looks at how certain immune cells called plasma cells may drive chronic rejection in people who have had lung transplants and how this could lead to new ways to protect the transplant.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11346016

• Automated frailty score from body shape and lung image for lung transplant candidates

  A new computer model will use pre-transplant CT scans to automatically score a candidate’s fitness for a lung transplant, aiming to improve outcomes and donor-lung allocation.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11346012

• B Cells and Lung Transplant Rejection: How B Cells Shape Ischemia-Reperfusion Injury

  This project studies how recipient B cells influence lung transplant injury and rejection after surgery, with the aim of improving long-term outcomes for patients who receive a lung transplant.

  NIH research Washington University · Saint Louis, United States · NIH-11342078

• Non-invasive infection detection after lung transplant

  A non-invasive blood test using phage-based signals could help doctors detect lung infections early in people who have had a lung transplant.

  NIH research Stanford University · Stanford, United States · NIH-11333348

• How lung B cells and antibodies change after a lung transplant

  This project looks at how B cells that live in the lung and the antibodies they make change over time in people who have had lung transplants and how they respond to infections, vaccines, or donor and self antigens.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11332864

• Understanding how immune regulation in lung transplant recipients could prevent chronic lung rejection

  This grant explores how immune cells in and around lung transplants keep the body from rejecting the new lung, with a focus on a special type of immune cell and its signals.

  NIH research Washington University · Saint Louis, United States · NIH-11330443

• Investigating the role of plasma cells in lung transplant rejection

  This study is looking at how certain immune cells, called plasma cells, might play a role in lung transplant rejection, especially for patients dealing with bronchiolitis obliterans syndrome, and it hopes to find new ways to help improve the success of lung transplants.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11181272

• A new scoring system to evaluate lung transplant candidates

  This study is working on a new tool to help doctors better understand how fit someone is for a lung transplant by looking at their chest scans, which could lead to better outcomes for patients like you.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11170712

• How body fat and muscle affect recovery and quality of life after lung transplant

  This research looks at whether body fat, muscle mass, and related body-measure tests predict complications, survival, and quality of life for people getting lung transplants.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11146424

• How body composition affects outcomes in lung transplantation

  This study is looking at how body weight and muscle health affect recovery and quality of life for people getting a lung transplant, so we can better support patients during their healing process.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11144645

• Understanding donor lung injury after lung transplant

  This research looks for hidden signs of injury in donor lungs to help more lung transplant patients have better outcomes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11139492

• Sending anti-rejection medicine directly to blood vessels in transplanted lungs

  This project tests tiny drug carriers that deliver anti-rejection medicine straight to the blood vessels of transplanted lungs to help people who receive lung transplants.

  NIH research Northwestern University · Chicago, United States · NIH-11136558

• Improving infection detection after lung transplants

  This study is looking for a better way to check for infections and rejection in lung transplant patients by using a simple blood test instead of more uncomfortable procedures, helping doctors catch problems early and improve recovery.

  NIH research Stanford University · Stanford, United States · NIH-11122308

• Improving lung transplant success by targeting immune responses

  This study is looking at new ways to help lung transplant patients by creating tiny agents that can deliver important medications directly to the lungs, helping to prevent the body from rejecting the new organ and improving overall transplant success.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11091934

• Understanding B cell and antibody responses in lung transplantation

  This study is looking at how certain immune cells called B cells work in the lungs of people who have had a lung transplant, especially how they respond to infections like COVID-19 and the flu, to find ways to better protect these patients and improve their immune health.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11075887

• Understanding chronic rejection after lung transplantation

  This study is looking at why some lung transplant patients experience ongoing rejection of their new lungs, and it aims to create tools that help doctors predict who might be at risk, so they can provide better, personalized care to improve patients' lives and chances of survival.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11005004

• Understanding how BMP9 signaling affects lung transplant outcomes

  This study is looking at how a special protein called BMP9 might help improve lung transplant outcomes by reducing damage that can happen during the surgery, which affects many patients, and it hopes to find new ways to make lung transplants safer and more successful.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10996899

• Understanding lung transplant complications and their causes

  This study is looking into the problems that can happen after a lung transplant, like primary graft dysfunction and chronic lung allograft dysfunction, to better understand how the immune system and lung cells work together, with the goal of helping patients live longer and healthier lives after their transplant.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10933919

• Using Siltuximab to treat antibody-mediated rejection after lung transplants

  This study is looking at how well Siltuximab, a medication that helps with immune responses, can help patients who are having problems after a lung transplant due to antibody-mediated rejection, with the goal of improving their health and recovery.

  NIH research University of Utah · Salt Lake City, United States · NIH-10925203

• Understanding frailty in lung transplant patients

  This study looks at how things like aging and body health can impact the recovery and well-being of people getting lung transplants, with the goal of finding ways to improve care and support for these patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10918576

• How body composition affects outcomes for lung transplant patients

  This study is looking at how body weight and muscle mass affect the health and recovery of people getting a lung transplant, with the goal of helping doctors better care for their patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10899478

• How memory T cells affect lung transplant rejection

  This study is looking at how certain immune cells in the lungs might cause problems for people who have had a lung transplant, specifically focusing on a condition called bronchiolitis obliterans syndrome, and it hopes to find ways to improve care for those patients by learning more about these cells.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10888252

• Understanding lung injury in transplant patients

  This study is looking at how hidden damage in donor lungs might cause problems after a lung transplant, and it aims to find early warning signs using special markers in the blood, which could help doctors take better care of patients getting new lungs.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10877722

• Understanding a severe form of lung transplant rejection

  This study is looking into restrictive allograft syndrome (RAS), a serious issue that can happen after lung transplants, to understand how certain immune cells and antibodies cause rejection, with the hope of finding better treatments to help lung transplant patients live longer and healthier lives.

  NIH research Emory University · Atlanta, United States · NIH-10749064

Related topics

Quick answers

How many Lung Transplantation clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (7 trials), Czechia (2 trials), Turkey (Türkiye) (1 trial), Netherlands (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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