Immunosuppressive neutrophils in lung transplant recipients
Official title: Immunosuppressive Neutrophils Modulate Alloimmune Responses After Lung Transplantation
Funded at Washington University · NIH-11387528 · Data updated 2026-11-12
This grant supports a clinician-scientist in studying how certain white blood cells may help prevent rejection after lung transplant.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $166,364 |
| NIH project number | 5K08HL181281-02 |
| Project ID | NIH-11387528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have or are waiting for lung transplants and whose care might be improved by strategies that modulate neutrophil behavior.
✕Less likely to help
Patients not undergoing or considering transplant-related therapies may not directly benefit.
What this research studies
Over five years, the physician-scientist will combine clinical insight with lab and imaging work to understand how IL-1β drives special neutrophils that can dampen immune attacks on a lung transplant. The project uses advanced imaging and bioinformatics to map how these cells develop, move, and influence T cell responses in the context of transplantation. Findings could point toward new ways to reduce rejection and improve transplant outcomes for patients. The training component aims to build independent research and leadership skills to advance patient care.
Why it matters
Potential benefit: If successful, this work could lead to therapies that promote immune tolerance and reduce lung transplant rejection.
How similar studies have gone: Preliminary data suggest IL-1β–driven neutrophils influence alloimmune responses, indicating a promising but exploratory path.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Bery, Amit Indra — Washington University
- Study coordinator: Bery, Amit Indra
Related research
Other NIH-funded projects on the same topics.
-
Body composition and outcomes after lung transplant
A patient-focused look at how body fat and muscle measurements around the time of lung transplant relate to recovery, complications, and quality of life after surgery.
-
Objective lung-donor quality tools to expand the transplant pool
A lung-transplant-focused project aims to use gene-based risk tools to better judge donor organs and prevent recipient lung dysfunction.
-
Bmp-Cx40 signaling to keep lung blood vessels calm after transplant
A study aims to keep blood vessels in transplanted lungs stable by boosting a specific signaling pathway to reduce injury after transplant.
-
Complement inhibition to protect transplanted lungs from early injury
A small early trial tests whether a drug that blocks a key part of the immune system can prevent damage to new lungs right after transplant.
-
Phase 1 trial of siltuximab for antibody-mediated rejection after lung transplant
A early-stage study tests whether siltuximab can help people who have antibody-mediated rejection after lung transplantation.
-
Targeted delivery of immune-suppressing agents to the lung graft to prevent rejection
A study at Northwestern University will test a new, targeted approach to prevent lung transplant rejection by delivering immune-suppressing drugs directly to the graft while blocking early signals that trigger rejection.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.