Understanding lung injury in transplant patients
Immunogenomic analysis of donor lung injury and its impact on clinical outcomes after lung transplantation
This study is looking at how hidden damage in donor lungs might cause problems after a lung transplant, and it aims to find early warning signs using special markers in the blood, which could help doctors take better care of patients getting new lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10877722 on NIH RePORTER |
What this research studies
This research investigates how unnoticed damage in donor lungs can lead to severe complications after lung transplantation. By analyzing biological markers, particularly donor-derived cell-free DNA, the study aims to identify early signs of lung injury that could predict poor outcomes for transplant recipients. The approach includes examining samples from lung transplant patients to understand the mechanisms behind inflammation and injury. This could lead to better monitoring and treatment strategies for patients undergoing lung transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have recently undergone lung transplantation.
Not a fit: Patients who are not candidates for lung transplantation or those with pre-existing severe lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve the survival rates and quality of life for lung transplant recipients by enabling earlier detection and intervention for lung injury.
How similar studies have performed: Previous studies have shown promise in using cell-free DNA as a biomarker for lung injury, indicating that this approach may lead to significant advancements in understanding transplant complications.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Shaver, Ciara M — Vanderbilt University Medical Center
- Study coordinator: Shaver, Ciara M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.