Condition

Heart Transplantation clinical trials and research

• 21Clinical trials
• 15NIH research projects
• 11Countries

Newest Heart Transplantation clinical trials

All recruiting trials (21)

• Nationwide Swedish program testing donor-derived cell-free DNA to monitor rejection after heart transplant

  This project tests whether a blood test measuring donor-derived cell-free DNA can help monitor rejection in adults who have had a heart transplant.

  Recruiting Karolinska Institutet · Stockholm · NCT07531784

• Metabolic deterioration after heart transplant determines outcomes

  We'll test whether worsening cardiac and systemic metabolism after a heart transplant predicts heart function and long-term survival in adult transplant recipients.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf, North Rhine-Westphalia · NCT07372820

• Mapping fat-cell sizes around the coronary arteries to trace inflammation

  This project will test whether differences in fat-cell size next to the coronary arteries can show how inflammation spreads in people having a heart transplant for advanced heart failure.

  Recruiting Institute for Clinical and Experimental Medicine · Prague · NCT07360925

• Multimodal analysis of heart biopsy samples

  This project will take one extra small heart biopsy during a clinically needed procedure to test whether detailed molecular and immune analyses can find disease-specific signatures in adults with cardiomyopathies, myocarditis, cardiac amyloidosis, or after heart transplant.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT07359690

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Cardiac rehabilitation cohort at Medicine Campus Davos to explore recovery

  This project will follow adults coming to Hochgebirgsklinik Davos for cardiac rehabilitation to see how their heart health and recovery progress over time.

  Recruiting Hochgebirgsklinik Davos · Davos, Kanton Graubünden · NCT07096973

• Predicting heart transplant outcomes using donor heart biopsies

  This study is testing if looking at tissue samples from donor hearts can help predict how well the transplanted hearts will work and if they'll be rejected by the recipient's body.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT06982404

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

• Using advanced methods to manage heart transplant patients

  This study is testing a new way to help doctors better manage heart transplant patients by using advanced data methods to spot those at higher risk for rejection and other complications.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06774794

• Cardiac imaging and biomarkers to help diagnose antibody mediated rejection after heart transplant

  This study tests whether MRI inflammation/fibrosis patterns and blood biomarkers can help identify antibody-mediated rejection in adults who recently received a heart transplant.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bari, Bari and 3 other locations · NCT06774365

• Creating an electronic registry for patients with advanced heart failure and heart transplantation

  This study is trying to create an electronic record system to track patients with advanced heart failure and heart transplants to better understand their health and hospital visits.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06773611

• Preventive catheter ablation for heart failure patients with ventricular arrhythmias

  This study is testing if a heart procedure called catheter ablation can help heart failure patients with irregular heartbeats live longer and feel better compared to standard treatment before they get a heart transplant.

  Recruiting Heart and Diabetes Center North-Rhine Westfalia · Bad Oeynhausen · NCT06556485

• Evaluating heart and muscle function during exercise in children with heart disease

  This study is testing how well the hearts and muscles of kids with heart disease work during exercise to see if a special workout program can help them get stronger and healthier.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06325280

• Comparing two solutions for heart transplantation in children

  This study is testing a new heart preservation solution called Custodiol-N to see if it is safer than the older version, Custodiol, for children getting their first heart transplant.

  Recruiting at 3 sites Phase 2 Dr. F. Köhler Chemie GmbH · Berlin and 2 other locations · NCT06032195

• Using hypertonic saline to prevent kidney injury after heart transplantation

  This study is testing if a special salt solution can help prevent kidney problems in people who are having heart transplants.

  Recruiting Phase 2 University of Sao Paulo General Hospital · São Paulo · NCT05909150

• Evaluating microvascular reactivity in heart transplant patients

  This study looks at how blood flow in small blood vessels changes in heart transplant patients before and two years after their surgery to see if it can help predict long-term health issues.

  Recruiting National Institute of Cardiology, Laranjeiras, Brazil · Rio de Janeiro · NCT05729009

• Using haemoadsorption during heart transplantation

  This study is testing if using a treatment called haemoadsorption during heart transplantation can help reduce inflammation and improve recovery outcomes for patients in the days following their surgery.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT05270902

• New imaging protocol for heart conditions

  This study is testing a new imaging method for heart conditions to see if it can improve diagnosis and treatment for over 10,000 patients with heart issues.

  Recruiting Fatebenefratelli Hospital · Benevento · NCT05081115

• Using thymic-derived Treg cells to prevent heart transplant rejection in children

  This study is testing if using special immune cells from the thymus can help prevent heart transplant rejection in young children.

  Recruiting Phase 1/2 Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT04924491

• Using Belatacept for Heart Transplant Recipients

  This study is testing if the medication Belatacept can safely help adults who have just received a heart transplant by improving their long-term health.

  Recruiting Phase 2 NYU Langone Health · New York, New York and 1 other locations · NCT04477629

• Impact of Donor Heart Function on Recipient Outcomes

  This study looks at how the condition of donor hearts affects the recovery and health of people receiving heart transplants to see if using slightly damaged hearts can help more patients in need.

  Recruiting Vastra Gotaland Region · Gothenburg, Västra Götaland County · NCT04393181

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeted immune treatments to protect donated hearts

  This project develops ways to send immune-suppressing medicines directly to the lymph nodes and the transplanted heart to help people with heart transplants avoid rejection while reducing side effects.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11481770

• IL-33 helps protect heart transplant patients from long-term rejection

  This grant studies how a natural molecule called IL-33 may shield heart transplant patients from ongoing immune damage and chronic rejection.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11386616

• Targeted mRNA delivery to improve heart transplants from donation after circulatory death

  This grant tests a new mRNA delivery approach to help donor hearts from donors after circulatory death survive and function better after transplant.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11368433

• Belatacept to reduce rejection and protect kidneys after a heart transplant

  This trial will compare continuing tacrolimus to gradually switching to belatacept over nine months in people receiving a first-time heart transplant to lower rejection, prevent donor-specific antibodies, and protect kidney function.

  NIH research New York University School of Medicine · New York, United States · NIH-11326277

• Partial heart transplant to give growing heart valves to children

  This work tries transplanting only the donor heart part that contains a valve so children can get a valve that grows with them.

  NIH research Arkansas Children's Hospital Res Inst · Little Rock, United States · NIH-11298389

• Predicting Heart Transplant Rejection Risk Before Surgery

  This research aims to find ways to predict which heart transplant patients might reject their new heart, helping doctors tailor their medication plans.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11180489

• How IL-33 may protect transplanted hearts

  This work looks at whether a natural protein called IL-33 can reduce inflammation and scarring after a heart transplant for transplant recipients.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11143100

• Improving Heart Transplant Decisions with Artificial Intelligence

  This research aims to create a smart computer program to help doctors make better decisions about matching donor hearts with patients who need them.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11092289

• Non-invasive heart MRI for transplant patients

  This work uses advanced cardiac MRI scans to find early, noninvasive signs of rejection and blood-vessel disease in people who have had a heart transplant.

  NIH research Northwestern University · Chicago, United States · NIH-11082986

• Understanding how certain immune cells affect heart transplant rejection

  This study is looking at how certain immune cells called CCR2- macrophages affect heart transplant rejection, with the hope of finding better ways to help heart transplant patients do well without relying too much on strong medications that can have side effects.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11077317

• Investigating a new treatment for heart transplant patients using Belatacept

  This study is looking at how well Belatacept works as a new option for people getting their first heart transplant, helping them safely switch from traditional medications while aiming to improve heart health and reduce rejection risks.

  NIH research New York University School of Medicine · New York, United States · NIH-11059177

• Improving immune therapies for heart transplant patients

  This study is looking for ways to make heart transplant treatments better by using new methods to help your body accept the new heart while reducing side effects, so if you're a heart transplant patient, you might get to try some exciting new therapies!

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11015852

• Identifying risks of heart transplant rejection before surgery

  This study is looking to help heart transplant patients by finding out who is less likely to reject their new heart before the surgery, so they can take fewer medications that might cause side effects and enjoy better long-term health.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10985915

• Understanding how IL-33 helps protect heart transplants

  This study is looking at how a substance called IL-33 can help reduce inflammation and support healing in kids who have received heart transplants, by understanding how it affects the immune system's response to the new heart.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10880447

• Using a cholesterol-lowering medication to prevent heart complications after transplantation

  This study is looking at how well a new cholesterol-lowering medication called alirocumab works for heart transplant patients to help keep their hearts healthy and prevent complications, and if you join, you'll either get the medication or a placebo while we check your heart health over a year.

  NIH research Stanford University · Stanford, United States · NIH-10617265

Related topics

Quick answers

How many Heart Transplantation clinical trials are recruiting right now?

21, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in Italy (5 trials), Germany (4 trials), Brazil (2 trials), Austria (2 trials), Sweden (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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