Understanding donor lung injury after lung transplant
Immunogenomic analysis of donor lung injury and its impact on clinical outcomes after lung transplantation
This research looks for hidden signs of injury in donor lungs to help more lung transplant patients have better outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11139492 on NIH RePORTER |
What this research studies
After a lung transplant, some donor lungs develop severe injury, which can lead to serious problems or even death for the patient. We believe there might be subtle, hidden injuries in donor lungs that make them more susceptible to damage once transplanted. This project aims to discover these early signs of injury by studying specific biological markers, such as cell-free DNA, and how they contribute to inflammation. Our goal is to better understand these processes so we can identify at-risk lungs and improve long-term success for transplant recipients.
Who could benefit from this research
Good fit: This research is most relevant to individuals who are awaiting or have recently received a lung transplant.
Not a fit: Patients who are not candidates for lung transplantation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify donor lungs at risk and improve the health and survival of lung transplant patients.
How similar studies have performed: While cell-free DNA has been identified as a biomarker for lung injury, this specific approach to understanding its role in subclinical donor lung injury and inflammation pathways is a new area of investigation.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Shaver, Ciara M — Vanderbilt University Medical Center
- Study coordinator: Shaver, Ciara M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.