Muscle health before and after lung transplant in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will characterize respiratory and limb muscle properties in adults waiting for lung transplantation and after transplant. Researchers will perform weekly ultrasound imaging of selected muscles, plus strength tests, physical performance measures, and symptom questionnaires before and after transplantation. Medical records will be reviewed for ICU stay, hospital stay, rehabilitation participation, and recovery outcomes to explore associations with muscle characteristics. The goal is to see whether muscle structure and strength help explain differences in mobility, frailty, symptoms, and recovery after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years or older.
* Hospitalized as potential candidates for single- or bilateral-lung transplant surgery.
* Hemodynamically stable for out-of-bed mobilization

Exclusion Criteria:

* Baseline cognitive impairment
* History of previous solid organ transplantation or thoracic surgery
* Existing phrenic nerve lesion
* Lower limb amputation or fracture
* External fixators or open wounds of the lower extremities
* Diagnosed neuromuscular disorder.
* Morbid obesity (body mass index \>45 kg/m²).
* Any other medical condition that, in the opinion of the investigators, would make participation unsuitable.

Where it's running

• UF Health Shands Medical Center
  Gainesville, Florida, United States Recruiting

Study contacts

• Study coordinator: Barbara K Smith, PhD, PT
• Email: bksmith@ufl.edu
• Phone: 352-294-5315

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.