Understanding lung transplant complications and their causes
Integrated mechanisms of primary and chronic graft dysfunction following lung transplantation
This study is looking into the problems that can happen after a lung transplant, like primary graft dysfunction and chronic lung allograft dysfunction, to better understand how the immune system and lung cells work together, with the goal of helping patients live longer and healthier lives after their transplant.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10933919 on NIH RePORTER |
What this research studies
This research investigates the complex mechanisms behind complications that arise after lung transplantation, particularly focusing on primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD). The team will explore how immune responses and lung cell interactions contribute to these issues, using advanced molecular techniques and animal models. Patients may be involved in studies that assess the role of specific antibodies and esophageal function in transplant outcomes, aiming to improve long-term survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have undergone or are scheduled for lung transplantation and may be at risk for complications like PGD or CLAD.
Not a fit: Patients who have not received a lung transplant or those with conditions unrelated to lung transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and managing complications after lung transplantation, ultimately enhancing patient survival and quality of life.
How similar studies have performed: Previous research has shown promising results in understanding graft dysfunction in other organ transplants, suggesting that this approach could yield valuable insights for lung transplantation as well.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Bharat, Ankit — Northwestern University at Chicago
- Study coordinator: Bharat, Ankit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.