Condition

Emphysema clinical trials and research

• 23Clinical trials
• 23NIH research projects
• 1New in 30 days
• 14Countries

Newest Emphysema clinical trials

All recruiting trials (23)

• Xenon MRI test for lung changes after Apreo BREATHE airway treatment in emphysema

  This study tests whether hyperpolarized Xenon MRI can show regional ventilation and gas-exchange changes after the Apreo BREATHE airway scaffolds in people with emphysema and air trapping.

  Recruiting Early Phase 1 Apreo Health, Inc. · Birmingham, Alabama and 1 other locations · NCT07896902

• Prediction score for death or lung transplant in emphysema caused by alpha-1 antitrypsin deficiency

  This study tests a new prediction tool to identify people with emphysema due to alpha-1-antitrypsin deficiency who are at high risk of death or needing a lung transplant.

  Recruiting at 4 sites University Hospital, Bordeaux · Bron and 3 other locations · NCT07715617

• Testing CE1226 doses to slow lung disease in adults with alpha-1 antitrypsin deficiency

  This trial tests two active doses of CE1226 to see if they slow lung density decline in adults with AAT deficiency and emphysema over 3 years compared with the standard 60 mg/kg dose.

  Recruiting at 2 sites Phase 4 CSL Behring · Aalborg and 1 other locations · NCT07326592

• Implant to help adults with severe emphysema

  This study will test whether an implantable artificial bronchus can improve breathing and safety in adults with severe COPD/emphysema.

  Recruiting at 4 sites Pulmair Medical, Inc. · San Francisco, California and 3 other locations · NCT07119229

• Endobronchial silicone valve to help breathing in people with severe emphysema

  This trial tests whether placing a silicone valve in the airways of one lung region can improve breathing for people with severe emphysema when added to usual care.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT07097896

• Implantable Artificial Bronchus 50 Flex for adults with severe emphysema

  This tests a small implant called the IAB 50 Flex to see if it is safe and helps adults with severe COPD or emphysema breathe and move more easily.

  Recruiting at 2 sites Pulmair Medical, Inc. · Limoges and 1 other locations · NCT07086339

• Multidisciplinary sarcopenia clinic to diagnose and treat muscle loss from COPD

  This project will try a multidisciplinary sarcopenia clinic to see if it improves muscle mass, function, and overall health for COPD patients with CT-confirmed muscle loss after a hospitalization.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07059637

• Bronchoscopic release of trapped air in hyperinflated emphysematous lungs

  This trial tests if placing permanent Apreo BREATHE airway scaffold implants by bronchoscopy, together with usual medical care, helps adults with COPD and emphysema who remain short of breath from lung hyperinflation.

  Recruiting at 23 sites Apreo Health, Inc. · Birmingham, Alabama and 22 other locations · NCT06891755

• Lung cancer screening program for patients with COPD or emphysema

  This study is testing if regular lung cancer screenings can help people with COPD or emphysema catch lung cancer earlier and live longer.

  Recruiting at 2 sites Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz · Madrid and 1 other locations · NCT06690385

• Endobronchial thermal liquid ablation for treating emphysema

  This study is testing a new treatment called endobronchial thermal liquid ablation to see if it can safely help people with severe emphysema breathe better and improve their quality of life.

  Recruiting at 2 sites Morair Medtech, LLC · Vienna, Austria and 6 other locations · NCT06655428

• Assessing lung health using ultrasound in emphysema patients

  This study is testing if lung ultrasound can help doctors better understand lung health in people with emphysema compared to healthy individuals and those with lung cancer.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Acquaviva delle Fonti and 3 other locations · NCT06533371

• Using breath analysis to identify multiple lung diseases

  This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.

  Recruiting ChromX Health · Guangzhou, Guangdong · NCT06528418

• Evaluating a new valve for lung volume reduction in COPD patients

  This study is testing a new valve to see if it can safely help people with COPD and emphysema breathe better and feel more active after a lung procedure.

  Recruiting China-Japan Friendship Hospital · Beijing, Beijing Municipality · NCT06349174

• Observational surveillance of Zephyr Valve use for severe emphysema in Japan

  This study is testing the use of the Zephyr Valve in 140 patients with severe emphysema in Japan to see how it affects their lung function, exercise ability, and quality of life over a year.

  Recruiting at 16 sites Pulmonx Corporation · Aichi and 16 other locations · NCT06332885

• Examining muscle function changes before and after endobronchial valve treatment for emphysema

  This study is testing how a specific lung treatment for severe emphysema affects muscle function in patients to see if it helps them feel better and move more easily.

  Recruiting University Medical Center Groningen · Groningen · NCT06025500

• Using voice and breathing tests to detect emphysema in COPD patients

  This study is testing whether voice and breathing tests can help find out how severe emphysema is in people with COPD.

  Recruiting Maastricht University · Maastricht, Limburg and 1 other locations · NCT05825261

• Understanding MMP12 levels in patients with emphysema

  This study is trying to see if measuring a specific protein in the sputum and blood of people with emphysema can help understand their lung condition and find better treatments.

  Recruiting McMaster University · Hamilton, Ontario · NCT04761393

• Comparing lung surgery and bronchoscopic treatment for severe emphysema

  This study is testing whether lung surgery or a less invasive bronchoscopic treatment works better for people with severe emphysema.

  Recruiting at 6 sites University of Zurich · Vienna and 5 other locations · NCT04537182

• Registry to evaluate the Spiration Valve System for severe emphysema

  This study is testing how well the Spiration Valve System works and how safe it is for adults with severe emphysema over three years after they receive the treatment.

  Recruiting at 16 sites Olympus Corporation of the Americas · Phoenix, Arizona and 15 other locations · NCT04302272

• Long-term follow-up for patients with COPD in Kingston

  This study is trying to create a better way to follow up with people in Kingston who have COPD by collecting important health information to improve their care and treatment.

  Recruiting Queen's University · Kingston, Ontario · NCT04200079

• Evaluating airflow limitation in COPD, emphysema, and asthma overlap

  This study is trying to see how airflow problems in chronic smokers with COPD, emphysema, and asthma overlap are caused by different parts of the lungs and how they relate to lung health.

  Recruiting at 2 sites Gelb, Arthur F., M.D. · Lakewood, California and 1 other locations · NCT03263130

• A patient registry for COPD research

  This study is gathering health information from over 75,000 people with COPD to help find better treatments and a cure for the disease.

  Recruiting COPD Foundation · Washington D.C., District of Columbia · NCT02803242

• Registry for patients with emphysema and COPD

  This study is collecting information from people with emphysema and COPD to help researchers learn more about these lung diseases and improve future treatments.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT00307281

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Precision phenotyping of emphysema in the elderly: a study in diverse adults

  Researchers will look at CT scans and lung tests in older adults to understand different forms of emphysema and how they relate to health outcomes.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11645204

• Lithium as a potential disease-modifying treatment for emphysema using a precision approach

  A low-dose lithium approach is being studied to slow or modify emphysema in smokers who have COPD.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11416473

• Imaging and multi-omics to find subtypes of emphysema in COPD

  This project looks for molecular subtypes of emphysema in COPD by combining imaging with blood and tissue data to improve understanding and treatment options.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11391042

• Precision phenotyping of emphysema in the elderly: the MESA Lung Study

  Aging adults with or without COPD-related symptoms may benefit from a new study that maps subtypes of emphysema on CT scans to better predict health risks.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11311266

• E-cigarette use and emphysema risk in young adults (VapeScan)

  A study to understand whether vaping or traditional cigarettes cause early lung damage in young adults.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11298469

• Loss of lung blood-vessel stem cells that may speed lung aging and raise emphysema risk

  Researchers will look at how losing a type of lung blood-vessel progenitor cell may make lungs age faster and increase emphysema risk in adults.

  NIH research National Jewish Health · Denver, United States · NIH-11257257

• Immune cells blocking lung repair stem cells in emphysema

  This project looks at how immune cells in the lungs may stop repair stem cells after viral infections in people with emphysema.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11251570

• CD55, a lung-protective protein, and how it may prevent smoke-related lung damage

  This project tests whether the protective protein CD55 can stop cigarette smoke from harming lung repair cells and slow emphysema in smokers and people with early COPD.

  NIH research University of Florida · Gainesville, United States · NIH-11248766

• Understanding How Smoking Causes Different Types of Lung Damage

  This research helps us understand why cigarette smoking can lead to different serious lung conditions like emphysema or lung scarring.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11177656

• Finding molecular types of emphysema using CT scans and blood tests

  This project uses CT lung images plus blood and lung-tissue tests to find different molecular types of emphysema in people with COPD.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11146689

• Natural inflammation‑resolving molecules and emphysema

  This project looks at whether higher blood levels of natural inflammation‑resolving molecules are linked to better breathing and less lung damage in people with emphysema.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11144318

• MIF Genes and Therapies for Emphysema

  This grant explores how a gene called MIF affects emphysema in COPD and tests ways to restore MIF to prevent severe lung infections.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11052963

• How immune cells affect lung stem cells in emphysema

  This study is looking at how certain immune cells in the lungs affect the healing stem cells in people with emphysema, aiming to find new ways to help improve lung health and prevent flare-ups.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11024845

• Understanding how loss of certain lung cells affects aging and emphysema risk

  This study is looking at how certain cells in the lungs, called mesenchymal vascular progenitors, change as we age and how their loss might lead to lung problems like emphysema, especially in people who smoke, with the hope of finding new ways to help improve lung health for older adults.

  NIH research National Jewish Health · Denver, United States · NIH-11017855

• Investigating how MIF and CD74 contribute to emphysema development

  This study is looking at how a protein called MIF might help protect lung cells from damage caused by smoking, with the goal of finding new ways to prevent or treat emphysema for people who are affected by this lung condition.

  NIH research Yale University · New Haven, United States · NIH-11009031

• Understanding combined pulmonary fibrosis and emphysema using advanced imaging techniques

  This study is looking at how to better understand and diagnose combined pulmonary fibrosis and emphysema (CPFE) by using advanced imaging techniques, so that patients can receive more accurate diagnoses and personalized treatment plans.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10995753

• Investigating how specialized molecules help reduce inflammation in emphysema

  This study is looking at how certain natural substances in the body can help reduce inflammation and improve lung health in people with emphysema, and it will track how these substances affect breathing and inflammation over time.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10972838

• Using doxycycline to slow emphysema in people living with HIV

  The DEPTH trial is testing whether the antibiotic doxycycline can help slow down emphysema in people living with HIV, and if you join, you'll either get doxycycline or a placebo for about a year and a half while we check how well your lungs are working.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10914045

• Identifying molecular subtypes of emphysema using imaging and multi-omics data

  This study is looking at different types of emphysema to better understand the disease and find new ways to treat it, and it involves patients sharing blood and lung tissue samples along with imaging tests.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10912814

• Using doxycycline to slow emphysema in people with HIV

  The DEPTH trial is looking at whether the antibiotic doxycycline can help slow down emphysema in people with well-controlled HIV who are current or former smokers, and you'll either get doxycycline or a placebo for 72 weeks to see how it affects your lung function.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-10911918

• Investigating B cells in patients with emphysema-predominant COPD

  This study is looking at how a type of immune cell called B cells acts in people with emphysema, a form of chronic lung disease, to see how these changes might be linked to lung damage, and it involves analyzing samples from patients to better understand what's happening in their lungs.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10906676

• Investigating how a protein protects lung cells from damage caused by cigarette smoke

  This study is looking at how cigarette smoke harms lung cells and whether a protein called CD55 can help protect them, with the goal of finding ways to prevent lung damage in smokers and identify those at risk for conditions like emphysema and COPD.

  NIH research University of Florida · Gainesville, United States · NIH-10876318

• Understanding how emphysema progresses in patients

  This study is looking at how emphysema, a serious lung condition, gets worse over time, using special scans to help doctors create more tailored treatment plans for patients based on their unique situation.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10593186

Related topics

Quick answers

How many Emphysema clinical trials are recruiting right now?

23, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (8 trials), Netherlands (5 trials), Austria (3 trials), China (3 trials), Denmark (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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