How memory T cells affect lung transplant rejection
Impact of tissue resident memory T cells on chronic rejection after lung transplantation
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10888252
This study is looking at how certain immune cells in the lungs might cause problems for people who have had a lung transplant, specifically focusing on a condition called bronchiolitis obliterans syndrome, and it hopes to find ways to improve care for those patients by learning more about these cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10888252 on ClinicalTrials.gov |
What this research studies
This research investigates the role of tissue resident memory T cells in the chronic rejection process following lung transplantation. It aims to understand how these immune cells contribute to bronchiolitis obliterans syndrome, a serious condition that affects many lung transplant recipients. By studying the persistence and generation of these T cells, the research seeks to uncover mechanisms that could lead to better management of chronic lung allograft dysfunction. Patients may be involved in providing samples or data to help advance this important area of immunology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation or are awaiting a lung transplant.
Not a fit: Patients who have not received a lung transplant or those with other unrelated chronic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing chronic rejection in lung transplant patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in transplant settings, indicating that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SNYDER, MARK EUGENE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: SNYDER, MARK EUGENE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury