Analyzing risk factors for lung transplant complications
Clinical Risk Factors for Primary Graft Dysfunction
University of Pennsylvania · NCT00552357
This study is trying to see if certain chemicals in the blood can help predict the risk of serious complications after lung transplants.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1150 (estimated) |
| Ages | 13 Years to 68 Years |
| Sex | All |
| Sponsor | University of Pennsylvania (other) |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT00552357 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on primary graft dysfunction (PGD), a serious complication that can occur after lung transplantation. Researchers will analyze blood samples from patients undergoing lung or heart-lung transplants to identify if elevated levels of certain chemicals are linked to an increased risk of developing PGD. Blood samples will be collected before surgery, immediately after, and 24 hours post-surgery, alongside a review of medical records. The findings aim to improve understanding of PGD and potentially guide future transplant eligibility criteria.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals scheduled for lung or combined heart and lung transplantation.
Not a fit: Patients undergoing combined organ transplantation other than heart and lung transplantation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify patients at higher risk for PGD, leading to better management strategies and improved outcomes after lung transplantation.
How similar studies have performed: While studies on PGD exist, this specific approach of analyzing blood markers for risk assessment is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing lung or combined heart and lung transplantation Exclusion Criteria: * Undergoing combined organ transplantation other than heart and lung transplantation
Where this trial is running
Philadelphia, Pennsylvania
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (RECRUITING)
Study contacts
- Principal investigator: Jason D. Christie, MD — University of Pennsylvania
- Study coordinator: E.J. Demissie, MSN
- Phone: 215-573-4767
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Primary Graft Dysfunction, Lung Transplantation