Analyzing risk factors for lung transplant complications

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on primary graft dysfunction (PGD), a serious complication that can occur after lung transplantation. Researchers will analyze blood samples from patients undergoing lung or heart-lung transplants to identify if elevated levels of certain chemicals are linked to an increased risk of developing PGD. Blood samples will be collected before surgery, immediately after, and 24 hours post-surgery, alongside a review of medical records. The findings aim to improve understanding of PGD and potentially guide future transplant eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Undergoing lung or combined heart and lung transplantation

Exclusion Criteria:

* Undergoing combined organ transplantation other than heart and lung transplantation

Where it's running

• University of Pennsylvania
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Jason D. Christie, MD — University of Pennsylvania
• Study coordinator: E.J. Demissie, MSN
• Phone: 215-573-4767

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CCR5 immune blockade to prevent primary graft dysfunction after lung transplant

  This trial will test whether the drug Maraviroc can prevent primary graft dysfunction in adults undergoing bilateral lung transplantation who have a PGD risk score greater than 50%.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT06853223

• Muscle health before and after lung transplant in adults

  This study tests how respiratory and leg muscle health relates to physical function and recovery in adults awaiting and after lung transplantation.

  Recruiting University of Florida · Gainesville, Florida · NCT07747337

• Prediction score for death or lung transplant in emphysema caused by alpha-1 antitrypsin deficiency

  This study tests a new prediction tool to identify people with emphysema due to alpha-1-antitrypsin deficiency who are at high risk of death or needing a lung transplant.

  Recruiting at 4 sites University Hospital, Bordeaux · Bron and 3 other locations · NCT07715617

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Temperature-controlled heart preservation system vs ice for primary graft dysfunction

  This study tests whether using the Xo Port Organ Preservation System can reduce severe graft dysfunction after heart transplant compared with traditional ice storage in adult recipients.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07230886

• Aerobic versus high-intensity interval exercise for people awaiting lung transplant

  This trial tests whether short bursts of high-intensity interval training or longer moderate aerobic sessions better improve walking distance and daily function for people with interstitial lung disease who are on the lung transplant waiting list.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT07065318

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.