Improving infection detection after lung transplants
Non-invasive Monitoring for Infections and Rejection after Lung Transplantation
This study is looking for a better way to check for infections and rejection in lung transplant patients by using a simple blood test instead of more uncomfortable procedures, helping doctors catch problems early and improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11122308 on NIH RePORTER |
What this research studies
This research focuses on developing non-invasive methods to monitor infections and rejection in lung transplant patients. By utilizing advanced techniques like Next Generation Sequencing of circulating free DNA (cfDNA) from blood samples, the study aims to identify microbial pathogens more accurately and efficiently. This approach seeks to overcome the limitations of current invasive diagnostic methods, such as bronchoalveolar lavage, which can be uncomfortable and impractical for patients. The goal is to enhance early detection of infections, ultimately improving patient outcomes after lung transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation and are at risk for infections or rejection.
Not a fit: Patients who have not received a lung transplant or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of infections in lung transplant patients, improving their long-term health and survival rates.
How similar studies have performed: Previous research has shown promise in using cfDNA for diagnostics in other medical fields, indicating potential for success in this novel application.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bollyky, Paul L — Stanford University
- Study coordinator: Bollyky, Paul L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.