Condition

Lung Adenocarcinoma clinical trials and research

• 31Clinical trials
• 49NIH research projects
• 18Countries

Newest Lung Adenocarcinoma clinical trials

All recruiting trials (31)

• DBC-664 in adults with solid tumors

  A first-in-human study will test DBC-664 to see if it is safe and tolerable in adults with various advanced solid tumors and may hint at anti-tumor activity.

  Recruiting at 7 sites Phase 1 TCG Labs Soleil · Denver, Colorado and 6 other locations · NCT07705035

• Ex Vivo Drug Response Testing in Lung Adenocarcinoma with Malignant Pleural Effusions

  This study tests whether the way cancer cells from pleural effusions respond to drugs outside the body can predict how patients will respond to treatment.

  Recruiting Sheba Medical Center · Ramat Gan, Israel · NCT07636252

• Vortioxetine for cognitive problems in ALK/ROS1-positive NSCLC treated with lorlatinib

  This observational study tests whether vortioxetine can help with cognitive and neurological side effects in adults with ALK/ROS1-positive NSCLC who are taking lorlatinib.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá · NCT07633626

• Targeted FSRT plus bevacizumab versus hippocampus-sparing whole-brain radiation for people with lung adenocarcinoma that has spread to the brain

  This will test whether focused 5-day fractionated stereotactic radiotherapy (FSRT) combined with bevacizumab works better than hippocampus-avoidant whole-brain radiotherapy with a simultaneous boost at controlling brain metastases and protecting memory in adults with lung adenocarcinoma and extensive brain metastases.

  Recruiting at 3 sites Phase 3 Sun Yat-sen University · Chongqing, Chongqing Municipality and 2 other locations · NCT07481786

• 7-day low-carb, high-fat (ketogenic) diet to improve FDG PET/CT detection of lepidic lung adenocarcinoma

  This trial will test whether a personalized 7-day ketogenic (low-carb, high-fat) diet before an FDG PET/CT can improve detection of lepidic-predominant lung adenocarcinoma in adults with a suspicious lung nodule or confirmed diagnosis.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Torino (TO) · NCT07479095

• Partial high-dose tumor irradiation combined with immunotherapy for unresectable lung adenocarcinoma

  This trial will try giving very high-dose radiation to the central part of large, unresectable lung adenocarcinomas while preserving the surrounding immune tissue and pairing that with an immune checkpoint drug for patients who have no remaining standard treatment options.

  Recruiting Karl Landsteiner University of Health Sciences · Krems, Austria · NCT07423169

• PHOENIX: QL1706 plus chemo and bevacizumab in high PD-L1, driver-mutant non-squamous NSCLC

  This trial tests if adding QL1706 to chemotherapy and bevacizumab can help patients with PD-L1 high, driver-mutant non-squamous NSCLC after TKIs.

  Recruiting at 2 sites Phase 2 Guangdong Association of Clinical Trials · Guangzhou, Guangdong,China and 1 other locations · NCT07416058

• SL-28 for Advanced Solid Tumours

  A new allogeneic cell therapy called SL-28 is being tested in adults with advanced solid tumors to see if it is safe and can help shrink tumors.

  Recruiting Phase 1/2 Second Life Therapeutics · Sydney, New South Wales and 2 other locations · NCT07341737

• Dapagliflozin before surgery for stage IA lung adenocarcinoma

  This trial tests if taking dapagliflozin for 30 days before surgery is safe for adults with stage IA lung adenocarcinoma.

  Recruiting Early Phase 1 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07235280

• Support for Veterans with lung cancer.

  This study will test whether weekly phone support from a trained lay health worker can improve quality of life for Veterans who are newly diagnosed with lung cancer or who finished treatment within the past year.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT07219251

• Pleural fluid biomarker testing to help diagnose lung adenocarcinoma

  This project will test whether measuring new molecular markers in pleural fluid can help diagnose lung adenocarcinoma in adults who need thoracentesis.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT07012759

• Clinical Application of PET Imaging Targeting MSLN in Malignant Tumors

  This study is testing if a special type of PET scan that targets a protein in cancer cells can help doctors find and treat malignant tumors better.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06843629

• Investigating lymph node patterns in lung adenocarcinoma

  This study looks at how different patterns in lymph nodes from lung adenocarcinoma patients can help predict their health outcomes after surgery.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT06745830

• Surgery for solid-dominant lung cancer

  This study is testing if a specific lung surgery called segmentectomy can help people with a certain type of lung cancer live longer and breathe better after the operation.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT06634966

• Observational study on characteristics and outcomes of patients with surgically removed lung cancers

  This study looks at patients in China who have had lung cancer surgery to see how their treatment and outcomes vary and what factors might affect their survival.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06255197

• Understanding genetic variants in lung adenocarcinoma among Mexican patients

  This study is trying to find out how common certain genetic changes are in Mexican patients under fifty with lung adenocarcinoma to better understand their condition.

  Recruiting Instituto Nacional de Cancerologia de Mexico · Mexico City, Mexico City · NCT06181812

• Using Tislelizumab and chemotherapy for lung cancer with brain metastases

  This study is testing if a new immune therapy combined with chemotherapy can help people with lung cancer that has spread to the brain but isn’t causing symptoms yet.

  Recruiting Hebei Medical University Fourth Hospital · Shijiazhuang, Hebei · NCT06056115

• Selective lymph node dissection for early-stage lung cancer

  This study is testing if a specific type of surgery called selective lymph node dissection can help people with early-stage lung cancer live longer and stay cancer-free.

  Recruiting Phase 3 Fudan University · Shanghai, Please Select · NCT06031246

• Surgery for early-stage lung adenocarcinoma using a less extensive approach

  This study is testing if a less invasive lung surgery can be effective for people with early-stage adenocarcinoma, helping them recover better than with traditional surgery.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT06031181

• Comparing two surgical methods for small lung tumors

  This study is testing whether two different types of lung surgery work better for people with small lung tumors to see which one helps them live longer without the cancer coming back.

  Recruiting Shanghai Pulmonary Hospital, Shanghai, China · Yangpu, Shanghai Municipality · NCT05838053

• Testing AZD5335 for advanced solid tumors

  This study is testing a new treatment called AZD5335, alone or with other cancer drugs, to see if it helps people with advanced ovarian cancer and lung adenocarcinoma.

  Recruiting at 55 sites Phase 1/2 AstraZeneca · Duarte, California and 59 other locations · NCT05797168

• Surgery for early-stage lung cancer with ground glass nodules

  This study is testing if a lung-sparing surgery called segmentectomy can help people with early-stage lung cancer live longer and breathe better after treatment.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT05717803

• Integrative platform for personalized lung cancer care using AI

  This study is trying to create a smart tool that helps doctors predict how well immunotherapy will work for people with non-small cell lung cancer, so they can make better treatment choices.

  Recruiting at 4 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Chicago, Illinois and 3 other locations · NCT05537922

• Using osimertinib to prevent progression of lung cancer nodules after surgery

  This study is testing if the drug osimertinib can help prevent lung cancer nodules from getting worse in patients who have had surgery for their cancer.

  Recruiting Phase 2 Samsung Medical Center · Seoul · NCT05528458

• Evaluating blood clotting parameters in cancer patients undergoing surgery

  This study is testing how blood clotting measurements in cancer patients before and after surgery can help predict complications and outcomes for those with different types of adenocarcinoma.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT05517811

• Combining Pembrolizumab, Bevacizumab, and Chemotherapy for Advanced Lung Cancer with ALK Mutation

  This study is testing a new combination of two drugs and chemotherapy to see if it helps people with advanced lung cancer that has an ALK mutation and hasn't improved with another treatment.

  Recruiting Phase 2 Hunan Province Tumor Hospital · Changsha, Hunan · NCT05266846

• Developing a Decision Aid for Lung Cancer Patients

  This study is trying to create a helpful tool for lung cancer patients to make better decisions about their treatment options by gathering input from patients and healthcare experts.

  Recruiting Sichuan Cancer Hospital and Research Institute · Chengdu, Sichuan · NCT05191485

• Comparing segmentectomy and lobectomy for small lung adenocarcinomas

  This study tests if a smaller surgery called segmentectomy is just as good as a larger surgery called lobectomy for people with small lung tumors to see which one helps them live longer and stay cancer-free.

  Recruiting at 14 sites Shanghai Pulmonary Hospital, Shanghai, China · Hefei, Anhui and 13 other locations · NCT04937283

• Combining cryoablation with immunotherapy for lung cancer treatment

  This study is testing if adding cryoablation to standard lung cancer treatment can help people with metastatic lung adenocarcinoma live longer.

  Recruiting Phase 3 Institut Bergonié · Bordeaux, Gironde · NCT04339218

• Gene modified immune cells for treating advanced melanoma and metastatic solid tumors

  This study is testing if modified immune cells can safely target and attack advanced melanoma and other solid tumors in patients after they receive chemotherapy.

  Recruiting at 3 sites Phase 1 Stanford University · Duarte, California and 2 other locations · NCT04119024

• Improving survival in patients with advanced lung cancer in Ohio

  This study is testing a new approach to help people with advanced lung cancer in Ohio live longer and feel better by using advanced genetic and immune system tests to guide their treatment.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT03199651

NIH-funded research (newest 40 of 49)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding a highly flexible cell state in lung cancer that worsens outcomes

  A doctor-scientist at Cedars-Sinai wants to learn how a highly adaptable lung cancer cell state drives disease progression and resistance to therapy, using models that resemble human tumors.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11505050

• Breaking cytokine loops in LKB1-mutant lung cancer and the immune system

  A researcher at NYU School of Medicine is studying why a common lung cancer subtype with a specific mutation doesn’t respond well to current immunotherapy, with the aim of finding new ways to improve treatment.

  NIH research New York University School of Medicine · New York, United States · NIH-11381978

• Lung Adenocarcinoma: From Genome Changes to New Therapies

  This NIH grant supports research on lung adenocarcinoma to better understand its genome changes and translate that knowledge into better diagnosis and treatments for patients.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11380915

• Understanding how lung cancer and immune cells influence each other in early lung cancer development

  A study looks at how lung cells and immune cells change together as early lung cancer (lung adenocarcinoma) develops, with the goal of finding points to intervene early.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11371145

• Targeting a cancer pathway to stop metastasis in SMARCA4-deficient lung cancer

  This grant aims to understand and interrupt a key pathway that drives spread of a specific type of lung cancer in people whose tumors have SMARCA4 mutations.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11361630

• Combining imaging and biopsy genes to spot aggressive vs. slow-growing early lung cancer before surgery

  Aimed at people with early-stage lung adenocarcinoma, this project tests a combined imaging and biopsy gene‑marker approach to better predict tumor aggressiveness before surgery.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11361072

• Aberrant glycogen in lung adenocarcinoma tumor growth

  A new project will study how abnormal glycogen in lung adenocarcinoma tumors may drive cancer growth and help identify targets for future therapies.

  NIH research University of Florida · Gainesville, United States · NIH-11350893

• Origins of lung adenocarcinoma from lung cells like AT1 and AT2

  A cancer research project is exploring where a common form of lung cancer starts in the lung’s air sacs and how it develops.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11348850

• Targeting LKB1-null lung cancer with the body’s innate immune system

  Researchers are studying why a common type of lung cancer with LKB1 mutations may be kept in check by the body’s innate immune system, and how this could help patients who don’t respond to traditional therapies.

  NIH research Emory University · Atlanta, United States · NIH-11337596

• Targeting NSD2 to treat lung adenocarcinoma

  Aimed at testing a new way to treat lung cancer by blocking NSD2, an epigenetic factor, to slow tumor growth in patients with lung adenocarcinoma.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11336816

• Cysteine: How it fuels lung cancer and ways to target it

  This grant studies how lung cancer cells use cysteine in their environment, challenging the idea that they mainly rely on a single import pathway.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11305646

• Targeting PD-1–Expressing Tumor-Associated Macrophages to Overcome Immunoresistant Lung Adenocarcinoma

  A patient-focused look at a study aiming to make immune therapies work better for lung cancer by targeting a specific type of immune cell inside tumors.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11277970

• How lung adenocarcinoma spreads and hides from the immune system

  This work looks at the specific lung cancer cells that let tumors spread and survive so better ways to prevent relapse can be found.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11265091

• How loss of SETD2 drives lung adenocarcinoma growth

  This project looks at whether cutting dietary methionine or using drugs that change methionine-related metabolism can slow lung cancers that have lost the SETD2 gene.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11240268

• Human stem cell models of lung adenocarcinoma

  This project builds improved lab-grown human lung cancer models from patient cells to better reflect how lung adenocarcinoma develops and responds to treatments.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11238552

• Mapping early lung changes that can lead to lung cancer

  This project uses low-dose CT scans and tumor DNA and immune markers to find patterns that predict which small lung nodules are likely to be dangerous for people at risk of lung cancer, especially veterans.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11212789

• A sperm-only protein called COX6B2 helps some lung cancers make extra energy

  This work explores how the sperm protein COX6B2 lets lung adenocarcinoma cells produce more energy and survive, which could point to new treatment options for people with this form of lung cancer.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11174447

• ADCK4‑NUMBL gene fusion linked to aggressive lung adenocarcinoma

  Researchers are looking at whether a specific gene fusion called ADCK4‑NUMBL is tied to more aggressive lung adenocarcinoma in patients whose tumors lack common driver mutations.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11174428

• Understanding highly adaptable cancer cells in lung adenocarcinoma

  This work explores how certain highly adaptable cancer cells contribute to lung adenocarcinoma growth and resistance to treatments.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11138420

• Understanding how lung cancer develops and interacts with the immune system

  This research aims to understand the very first steps of lung adenocarcinoma development and how it interacts with the body's immune system.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11135449

• Targeting genetic changes in lung adenocarcinoma

  Looking at genetic changes in lung adenocarcinoma to find new targeted treatments for people with this cancer.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11131217

• Stopping the spread of lung cancer in patients with a specific gene change

  This research aims to find new ways to prevent lung cancer from spreading in patients who have a particular genetic change called SMARCA4 deficiency.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11129917

• Improving early lung cancer detection using imaging and biopsy markers

  This project aims to find better ways to tell if early-stage lung cancer is slow-growing or aggressive before surgery, using imaging and biopsy information.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11123905

• Boosting Natural Immunity for a Specific Type of Lung Cancer

  This research looks at how the body's own immune system might fight a specific type of lung cancer that often doesn't respond to other treatments.

  NIH research Emory University · Atlanta, United States · NIH-11121840

• Understanding Unusual Glycogen in Lung Cancer Growth

  This project explores how unusual glycogen, a type of sugar storage, contributes to the growth of lung adenocarcinoma, the most common type of lung cancer.

  NIH research University of Florida · Gainesville, United States · NIH-11109727

• Investigating how SETD2 gene changes affect lung cancer driven by EGFR and KRAS mutations

  This study is looking at how certain gene changes in lung cancer, especially the SETD2 gene, work together with other mutations to affect tumor growth, and it hopes to find new ways to treat patients based on their unique genetic makeup.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11088872

• Targeting a specific protein to treat lung adenocarcinoma

  This study is looking at how a protein called NSD2 affects lung adenocarcinoma, the most common type of lung cancer, to help create a new treatment that could work better for patients by targeting this protein.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11085121

• Investigating how TLE1 affects the aggressiveness of lung adenocarcinoma

  This study is looking at a protein called TLE1 to see how it helps lung adenocarcinoma cells survive and grow, even when they usually shouldn't, with the hope of finding new ways to treat this tough type of lung cancer.

  NIH research Xavier University of Louisiana · New Orleans, United States · NIH-11081675

• LKB1-linked immune resistance in lung cancer and new therapies

  Researchers are testing new ways to treat a common lung cancer subtype by targeting how LKB1 mutations suppress the immune response and make tumors harder to treat.

  NIH research Emory University · Atlanta, United States · NIH-11076735

• Creating human models to study lung adenocarcinoma

  This study is working on creating better models of lung adenocarcinoma, a common type of lung cancer, using samples from real patients to help researchers learn more about the disease and find more effective treatments just for you.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11041540

• Investigating how loss of a specific tumor suppressor affects lung cancer growth

  This study is looking at how a missing protein called BRG1 affects a cancer-related gene called GLI1 in lung adenocarcinoma, with the goal of finding new treatment options for patients whose cancer is linked to the loss of BRG1.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11039974

• Understanding how glucose transport varies in lung adenocarcinoma

  This study is looking at how a specific sugar transporter in your body affects lung cancer, especially in its early stages, to help us understand how the disease grows and find better ways to treat it.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11013894

• Understanding how SETD2 inactivation affects lung adenocarcinoma growth

  This study is looking at how a gene called SETD2 affects lung adenocarcinoma, a common lung cancer, and will test if certain diets and medications can help slow down tumor growth in patients with this gene issue.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10989950

• Investigating how a specific pathway affects the spread of lung cancer lacking a key protein.

  This study is looking at how a missing protein in a type of lung cancer affects its ability to spread, and it hopes to find new ways to treat patients by understanding the genetic changes involved.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10982146

• Mapping early changes in lung adenocarcinoma to improve patient outcomes

  This study is looking at how lung adenocarcinoma, a common type of lung cancer, changes early on to help doctors figure out which tumors are more aggressive and how best to treat them, using genetic tests and advanced imaging techniques.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-10950350

• Investigating the role of glycogen in lung adenocarcinoma development

  This study is looking at how glycogen affects the growth of lung adenocarcinoma, a common type of lung cancer, and aims to find new ways to understand and treat it better by using advanced imaging to see glycogen levels in lung tissues from patients.

  NIH research University of Florida · Gainesville, United States · NIH-10904804

• Understanding how certain factors influence lung cancer development

  This study is looking at how certain proteins in lung cancer cells work together and change to help the cancer grow, with the hope that this information can lead to new treatments for patients with lung adenocarcinoma.

  NIH research University of Utah · Salt Lake City, United States · NIH-10897198

• Investigating how a sperm protein affects lung cancer metabolism

  This study is looking at a protein called COX6B2, which helps cancer cells grow by boosting their energy, and it aims to find out how this works so that new treatments can be developed for lung cancer patients.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10894884

• Exploring how ancestry affects lung adenocarcinoma

  This study is looking at how genetic differences in lung cancer might vary among people from different backgrounds, and it aims to find ways to personalize prevention and treatment for patients based on their ancestry.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10892072

• Understanding how a flexible cell type affects lung cancer

  This study is looking at how certain flexible cells in lung adenocarcinoma, a type of lung cancer, help the tumors grow and resist treatments, with the hope of finding ways to improve outcomes for patients.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10888274

Related topics

Quick answers

How many Lung Adenocarcinoma clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in China (15 trials), United States (8 trials), Israel (3 trials), Australia (2 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 6, Phase 2: 3, Phase 1/2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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