Understanding a highly flexible cell state in lung cancer that worsens outcomes
Official title: Determining the role and function of a high plasticity cell state in lung adenocarcinoma
Funded at Cedars-Sinai Medical Center · NIH-11505050 · Data updated 2026-11-12
A doctor-scientist at Cedars-Sinai wants to learn how a highly adaptable lung cancer cell state drives disease progression and resistance to therapy, using models that resemble human tumors.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 22, 2022 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $160,648 |
| NIH project number | 7K08CA267072-05 |
| Project ID | NIH-11505050 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with lung adenocarcinoma or related tumors could benefit from future therapies developed from this work.
✕Less likely to help
Patients without the specific high plasticity cell state may not see direct benefits from this research.
What this research studies
This grant focuses on a specific lung cancer cell state that appears in many tumors and may help them spread and resist treatment. The team will study how this cell state behaves in mouse models and compare it to human tumors, looking for the signals that keep it switching and thriving. They will test how this state influences tumor growth, response to chemotherapy, and the ability to form new tumor tissue. The goal is to uncover real weaknesses in this cell state that could guide new treatment approaches.
Why it matters
Potential benefit: If successful, findings could lead to new strategies to prevent therapy resistance and slow lung cancer progression.
How similar studies have gone: Prior work has linked similar plastic cell states to worse outcomes, suggesting potential for meaningful impact but still early.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Chan, Jason Earl — Cedars-Sinai Medical Center
- Study coordinator: Chan, Jason Earl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.