Investigating how a specific pathway affects the spread of lung cancer lacking a key protein.
Targeting the ROR2/p-GSK3bS9 pathway to suppress metastasis in SMARCA4-deficient lung adenocarcinoma
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10982146
This study is looking at how a missing protein in a type of lung cancer affects its ability to spread, and it hopes to find new ways to treat patients by understanding the genetic changes involved.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10982146 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the absence of the SMARCA4 protein in lung adenocarcinoma contributes to the cancer's ability to spread to other parts of the body. By examining the ROR2/p-GSK3βS9 pathway, the researchers aim to uncover the mechanisms that drive metastasis in patients with this type of lung cancer. The study employs advanced techniques such as RNA sequencing and chromatin accessibility assays to analyze the genetic changes associated with cancer progression. Patients may benefit from insights that could lead to new therapeutic strategies targeting this pathway.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with SMARCA4-deficient lung adenocarcinoma.
Not a fit: Patients with lung cancer that does not involve SMARCA4 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically inhibit the spread of lung cancer in patients lacking SMARCA4.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONES, DAVID R — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: JONES, DAVID R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.