Condition

Lung Cancer (NSCLC) clinical trials and research

• 58Clinical trials
• 5NIH research projects
• 2New in 30 days
• 23Countries

Newest Lung Cancer (NSCLC) clinical trials

All recruiting trials (58)

• Integrated genomic and clinical database for cancer biomarker discovery

  Researchers are building a combined genomic and clinical database at Samsung Medical Center to test biomarkers for cancer diagnosis, treatment choice, and predicting how well treatments work.

  Recruiting Samsung Medical Center · Seoul, Gang-Nam · NCT07911267

• Understanding what patients want from NSCLC treatment monitoring

  Researchers are testing how patients with non-small cell lung cancer feel about and prefer monitoring their symptoms during treatment, with input from patients, caregivers, and clinicians.

  Recruiting European Institute of Oncology · Milan, mI · NCT07909343

• PD-L1-targeted PET probe to map PD-L1 in solid tumors

  A PET tracer called 18F-F-PDL1-3 is being tested to see if it can detect PD-L1 expression in primary and metastatic tumors to help guide personalized treatment.

  Recruiting Phase 2 Peking University Cancer Hospital & Institute · Beijing · NCT07848243

• Cardiorespiratory fitness after lobectomy versus sublobar resection in NSCLC

  This study tests how different lung surgeries (lobectomy vs. sublobar resection) affect fitness levels after surgery in people with non-small cell lung cancer.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT07841249

• CAIX-targeted PET/CT imaging in solid tumors

  Researchers are testing a CAIX-targeted PET/CT imaging agent to see if it detects and reflects CAIX levels in solid tumors like clear cell renal cell carcinoma, NSCLC, and breast cancer.

  Recruiting Zhongnan Hospital · Wuhan, Hubei · NCT07833085

• NUT Project: Nutritional Support in Thoracic Cancer

  We’ll see if providing tailored nutrition guidance and assessment helps people with advanced lung cancer during their treatment.

  Recruiting Casa di Cura Dott. Pederzoli · Peschiera del Garda, Verona · NCT07817329

• Single-Port Robotic Lobectomy for Early-Stage NSCLC

  This study tests the safety and outcomes of using the da Vinci Single-Port system for lobectomy and lymph node dissection in people with early-stage non-small cell lung cancer.

  Recruiting European Institute of Oncology · Milan, Mi · NCT07790406

• Brain-avoiding proton craniospinal irradiation for leptomeningeal metastases

  This study tests BRAVO pCSI, a proton therapy approach that avoids certain brain regions, to see if it helps adults with leptomeningeal metastases from solid tumors.

  Recruiting University of Miami · Miami, Florida · NCT07789912

• Fungal microbiota in NSCLC and its clinical relevance

  This study tests how lung fungi relate to different NSCLC subtypes, stages, and patient outcomes using tissue samples from surgery.

  Recruiting 958th Army Hospital of the Chinese People's Liberation Army · Chongqing, Liangjiang New · NCT07783971

• First-line treatment with pembrolizumab, pemetrexed, and platinum with or without zoldonrasib for metastatic non-squamous NSCLC

  This trial tests whether adding zoldonrasib to standard pembrolizumab and platinum chemotherapy helps people with untreated metastatic non-squamous NSCLC that has a RAS G12D mutation.

  Recruiting at 4 sites Phase 3 Revolution Medicines, Inc. · Anchorage, Alaska and 3 other locations · NCT07777822

• Health for Hungary: Long-term blood and health data collection to study aging and disease onset

  This study tests whether routine blood tests plus advanced molecular analyses can help detect the early stages of non-communicable diseases in adults over 40.

  Recruiting at 21 sites Center for Molecular Fingerprinting Research Nonprofit LLC · Balatonfüred and 32 other locations · NCT07743021

• Visual feedback in inspiratory muscle training after lobectomy

  This study tests whether adding a mobile app with visual feedback to inspiratory muscle training helps lung cancer patients after lobectomy by improving motivation, adherence, and comfort while breathing.

  Recruiting Hacettepe University · Ankara, Altındağ · NCT07646288

• PF-08634404 Alone or with chemotherapy in early-stage or locally advanced NSCLC

  This study tests PF-08634404 by itself or with chemotherapy in adults with early-stage or locally advanced non-small cell lung cancer that may be surgically removable or were candidates for additional therapy after initial treatment.

  Recruiting at 28 sites Phase 2 Pfizer · Huntsville, Alabama and 36 other locations · NCT07489066

• Lung MRI to identify immune patterns in non-small cell lung cancer

  This will see if combining different MRI measurements of the lung can create imaging signatures that identify immune-related patterns in people with primary non-small cell lung cancer.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia · NCT07486219

• Garsorasib and Ivonescimab with Chemo Before Surgery for KRAS G12C NSCLC

  This trial tests whether giving garsorasib followed by ivonescimab with chemotherapy before surgery helps people with resectable KRAS G12C-mutant NSCLC.

  Recruiting Phase 2 Guangdong Provincial People's Hospital · Guangzhou, Guangdong,China · NCT07472478

• Whole-body HER2 PET/CT to see how 89Zr-trastuzumab accumulates in HER2-positive or HER2-mutated advanced NSCLC

  This study tests whether 89Zr-trastuzumab PET/CT can show how much tracer builds up in tumors of adults with HER2-positive or HER2-mutated advanced NSCLC.

  Recruiting Phase 1 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT07436858

• Rehabilitation benefits for advanced NSCLC patients with stable disease after 6+ months of treatment

  This study tests a 3-month rehabilitation program to see how it helps people with advanced NSCLC who have had stable disease for at least 6 months.

  Recruiting University Hospital, Grenoble · Annecy and 2 other locations · NCT07434947

• Wedge Rreamoval? (Note: this looks wrong)**

  Test whether sublobar wedge resection or SBRT work better for high‑risk patients with early-stage NSCLC.

  Recruiting at 4 sites Aarhus University Hospital · Copenhagen, Copenhagen and 3 other locations · NCT07432802

• Ivonescimab alone or with carboplatin/pemetrexed for advanced NSCLC with actionable alterations

  This trial tests if ivonescimab, alone or with chemotherapy, can shrink tumors in advanced NSCLC patients who have actionable genomic alterations after prior targeted therapies.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT07405190

• Motion tracking during lung cancer radiotherapy using real-time MRI

  A trial tests real-time tracking of lung tumor motion during radiation therapy in adults with certain stages of NSCLC to see if MRI can help guide treatment.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT07398209

• SH009 injection for advanced solid tumors

  This trial will test whether SH009 injections are safe and can shrink or slow advanced solid tumors in adults with cancers such as liver, lung, breast, head and neck, and esophageal cancer who have progressed after prior treatment.

  Recruiting Phase 1 Nanjing Sanhome Pharmaceutical, Co., Ltd. · Shanghai · NCT07390838

• Local ablative therapy added to osimertinib for EGFR‑mutant metastatic NSCLC with few remaining tumor sites

  This trial tests whether adding local ablative therapy to ongoing osimertinib helps people with EGFR exon 19 or exon 21 L858R mutated stage IV non‑small cell lung cancer who have three or fewer active tumor sites after initial treatment.

  Recruiting Phase 2 Chinese University of Hong Kong · Hong Kong · NCT07379476

• RMC-5127 for advanced cancers with KRAS G12V mutation

  This trial will test whether the experimental drug RMC-5127, alone or with daraxonrasib or cetuximab, helps adults with advanced KRAS G12V-mutant solid tumors.

  Recruiting at 9 sites Phase 1 Revolution Medicines, Inc. · New Haven, Connecticut and 8 other locations · NCT07349537

• SL-28 for Advanced Solid Tumours

  A new allogeneic cell therapy called SL-28 is being tested in adults with advanced solid tumors to see if it is safe and can help shrink tumors.

  Recruiting Phase 1/2 Second Life Therapeutics · Sydney, New South Wales and 2 other locations · NCT07341737

• Using blood methylation markers to monitor early-stage NSCLC after Co‑ablation

  This project will try a blood methylation test to see if it can find tiny amounts of lung cancer DNA after co‑ablation treatment in people with early-stage non‑small cell lung cancer who cannot have surgery.

  Recruiting Beijing Haidian Hospital · Beijing, Beijing Municipality · NCT07257471

• Using blood methylation markers to detect recurrence and monitor minimal residual disease in lung cancer

  This project will test whether tracking two blood DNA methylation markers (SHOX2 and PTGER4) can detect minimal residual disease and predict recurrence in patients after non-small cell lung cancer surgery.

  Recruiting Beijing Haidian Hospital · Beijing, Beijing Municipality · NCT07257458

• Support for Veterans with lung cancer.

  This study will test whether weekly phone support from a trained lay health worker can improve quality of life for Veterans who are newly diagnosed with lung cancer or who finished treatment within the past year.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT07219251

• High-dose dexamethasone to reduce pain after VATS lung surgery

  This trial will test whether a single high IV dose of dexamethasone given at anesthesia induction reduces morning coughing pain after VATS lobectomy or segmentectomy for patients who score high on the Pain Catastrophizing Scale.

  Recruiting Phase 2/3 Copenhagen University Hospital, Rigshospitalet · Copenhagen, Copenhagen · NCT07213375

• Oral JBI-802 alone or with pembrolizumab for non-small cell lung cancer with an STK11 mutation

  This will test whether taking oral JBI-802 by itself or together with pembrolizumab helps people with advanced non-small cell lung cancer that has an STK11 mutation.

  Recruiting Phase 2 The Christ Hospital · Cincinnati, Ohio · NCT07207395

• Personalized dendritic cell and natural killer cell therapy for advanced NSCLC

  This trial will test whether giving people with advanced non-small cell lung cancer infusions of their own lab-grown dendritic cells (into an axillary lymph node) and natural killer cells (by IV) is safe and helps the NK cells kill tumors.

  Recruiting Phase 2 National Taiwan University Hospital · Huwei, YUNLIN · NCT07202611

• TJ101 for adults with advanced or metastatic solid tumors: finding a safe dose and checking for tumor response

  This trial tests TJ101, an experimental antibody‑drug given by IV, to see if it is safe and can shrink tumors in adults with advanced or metastatic solid cancers who have run out of standard treatment options.

  Recruiting at 4 sites Phase 1 Phrontline Biopharma · Orlando, Florida and 6 other locations · NCT07181473

• PHN-012 for people with advanced colon, lung (NSCLC), or pancreatic cancer.

  This trial will try PHN-012, a new antibody-drug conjugate, in people with advanced colon, non-small cell lung, or pancreatic cancer who have already received other treatments.

  Recruiting at 26 sites Phase 1 Pheon Therapeutics · Los Angeles, California and 25 other locations · NCT07127874

• Adjuvant tislelizumab after surgery for high-risk stage I non-small cell lung cancer

  This trial tests whether giving the immunotherapy drug tislelizumab for up to one year after complete surgery helps people with high-risk stage I non-small cell lung cancer whose tumors express PD-L1.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT07120282

• Neoadjuvant chemotherapy and dual immunotherapy with chemoradiation for unresectable stage III non-small cell lung cancer

  This trial will test whether giving two immune checkpoint drugs before and after chemoradiation, along with targeted agents, helps people with unresectable stage III non-small cell lung cancer.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT07103395

• Zusanli (ST36) electroacupuncture plus immunotherapy in NSCLC before surgery

  This trial tests whether adding electroacupuncture at ST36 to standard neoadjuvant immunotherapy helps patients with NSCLC better respond to treatment.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07076836

• Structured exercise and nutrition program for people with early-stage non-small cell lung cancer

  This trial tests whether a structured exercise and nutrition program can improve treatment response and disease-free survival for people with early-stage non-small cell lung cancer receiving neoadjuvant or adjuvant therapy.

  Recruiting Universita di Verona · Verona · NCT07042724

• Weekly low-dose oral vinorelbine plus PD-1 immunotherapy for older adults with advanced NSCLC

  This project tries weekly low-dose oral vinorelbine together with PD‑1 immunotherapy to see if it helps people 65 and older with unresectable advanced non‑small cell lung cancer.

  Recruiting Anhui Chest Hospital · Hefei, Anhui · NCT07041320

• Blood levels of immune checkpoint antibodies and their links to inflammation, cachexia, and response in lung cancer

  Test whether blood concentrations and how the body handles immune checkpoint antibodies relate to inflammation, weight loss (cachexia), and treatment response in adults with lung cancer starting immunotherapy.

  Recruiting University Hospital, Tours · Tours · NCT07004868

• Practical geriatric assessment for older adults with early-stage non-small cell lung cancer receiving SBRT

  This project will test whether a brief Practical Geriatric Assessment (PGA) can be used with adults 65+ who have stage I–II non-small cell lung cancer and are receiving stereotactic body radiation therapy to identify care needs and guide supportive referrals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06987890

• Sugemalimab with chemotherapy before surgery and continued after for resectable stage II–IIIA non-small cell lung cancer

  This study will test whether giving sugemalimab with chemotherapy before surgery and continuing sugemalimab after surgery helps adults with resectable stage II–IIIA non-small cell lung cancer who do not have EGFR or ALK mutations.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT06987734

• Evaluating neoadjuvant immunotherapy for lung cancer treatment outcomes

  This study is trying to see if giving immunotherapy before surgery helps people with non-small cell lung cancer live longer and feel better.

  Recruiting at 4 sites Peking University Cancer Hospital & Institute · Beijing, Beijing Municipality and 3 other locations · NCT06926179

• Almonertinib after one‑lung surgery for suspected cancer nodules in the other lung of EGFR‑mutant NSCLC patients

  This test tries whether three months of the EGFR blocker almonertinib can shrink or control suspected cancer nodules in the opposite lung of people with EGFR‑mutant non‑small cell lung cancer who already had one lung removed.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06924398

• Cryobiopsy for lung cancer lymph nodes

  This study is testing a new way to take tissue samples from lymph nodes in lung cancer patients using freezing techniques to see if it gives better results than the usual methods.

  Recruiting University of Zurich · Basel · NCT06921681

• Using liquid biopsy from EBUS-TBNA fluid to diagnose lung cancer

  This study is testing if analyzing fluid from a specific lung procedure can help diagnose lung cancer in patients who are suspected to have it but have had negative test results.

  Recruiting Barzilai Medical Center · Ashkelon · NCT06889467

• Testing blood samples for lung cancer treatment response

  This study is testing if blood tests can show how well immune therapy works for people with advanced lung cancer who can't have surgery.

  Recruiting Ballad Health · Kingsport, Tennessee · NCT06849518

• Longitudinal analysis of lung cancer using tissue and blood samples.

  This study is trying to see if changes in blood and tissue samples from lung cancer patients can help doctors tell the difference between harmless and harmful lung nodules and improve treatment plans.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06843707

• Air pollution biomarkers in people with COPD, lung cancer, and leukemia

  This project will test whether air pollution-related biomarkers appear in never-smokers with COPD, non-small cell lung cancer, or leukemia compared with healthy volunteers.

  Recruiting at 3 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 2 other locations · NCT06800586

• Comparing standard care to early palliative care for advanced lung cancer patients

  This study tests if adding early palliative care to standard treatment can help improve the quality of life and survival for people with advanced lung cancer.

  Recruiting Mahidol University · Bangkok · NCT06786468

• Preoperative treatment for lung cancer with amivantamab and chemotherapy

  This study is testing if giving a new antibody treatment called amivantamab before surgery can help patients with certain types of lung cancer feel better and improve their outcomes.

  Recruiting at 4 sites Phase 2 University Hospital, Essen · Hasselt and 3 other locations · NCT06784791

• Examining the link between residual tumor and outcomes after targeted therapy in lung cancer

  This study looks at how leftover tumor tissue after treatment affects survival in patients with a specific type of lung cancer who have received targeted therapy.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT06771960

• Eliminating margins in radiotherapy for early-stage lung cancer

  This study tests if removing extra safety margins in radiation treatment can help patients with early-stage lung cancer get better results while adapting to changes in their tumor's position.

  Recruiting Phase 2 Sun Yat-sen University · Guangzhou, Guangdong · NCT06730295

• AI blood test using platelet and immune-cell RNA for early cancer detection and monitoring

  This AI-based blood test profiles platelet and immune-cell RNA to see if it can find common cancers early and track treatment response in adults aged 40 and older.

  Recruiting at 2 sites Dysplasia Diagnostics Limited · Rosario and 3 other locations · NCT06717295

• Preparing lung cancer patients for surgery with a home program

  This study is testing a home program that helps lung cancer patients get stronger and healthier before their surgery through exercise and support from a physiotherapist.

  Recruiting University of Melbourne · Parkville, Victoria · NCT06716437

• Intrathecal treatment for lung cancer with leptomeningeal metastases

  This study is testing a new way to deliver two cancer drugs directly into the spine to see if it helps people with lung cancer that has spread to the brain and who haven't responded well to other treatments.

  Recruiting Phase 1 Shanghai Chest Hospital · Shanghai · NCT06663306

• Selective lymph node removal for small non-small cell lung cancer

  This study is testing a new surgery method that aims to safely remove fewer lymph nodes in patients with small non-small cell lung cancer to see if it leads to better recovery and fewer complications.

  Recruiting Fudan University · Shanghai · NCT06634979

• Comparing Stereotactic Body Radiotherapy with Immunochemotherapy for Lung Cancer

  This study is testing whether combining a specific type of radiation therapy with immunochemotherapy can help people with early-stage lung cancer do better than just using immunochemotherapy alone before surgery.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT06598527

• Tumor-infiltrating lymphocyte (TIL) therapy for advanced NSCLC

  This trial will try using a patient's own tumor-infiltrating lymphocytes, given after short chemotherapy and IL-2, to shrink tumors in adults with advanced NSCLC who have progressed after standard treatments.

  Recruiting Phase 2 University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT06455917

• Treatment of advanced lung cancer using KB707

  This study is testing a new treatment called KB707 to see if it can help adults with advanced lung cancer by boosting their immune response, especially for those who haven't had success with standard therapies.

  Recruiting at 10 sites Phase 1/2 Krystal Biotech, Inc. · Dothan, Alabama and 13 other locations · NCT06228326

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How air pollution and neighborhood stress affect lung tumors in African American patients

  This project looks at whether long-term air pollution and neighborhood disadvantage change tumor DNA and short-term recurrence risk in early-stage lung cancer among African American patients.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11379068

• Improving Immunotherapy for Lung Cancer with CT Scans

  This work aims to find new ways to predict which non-small cell lung cancer patients will respond best to immunotherapy using information from their routine CT scans.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11193547

• Targeting EGFR‑mutant lung cancer cells that resist targeted drugs

  This project tests lab and translational approaches to eliminate EGFR‑mutant lung cancer cells that survive targeted drugs, for people with EGFR‑positive non‑small cell lung cancer.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11188967

• Targeting resistant cells in lung cancer treatment

  This study is looking at why some lung cancer cells don't respond to certain treatments and aims to find new ways to help patients get better by targeting those stubborn cells, which could lead to longer-lasting results.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10926884

• Investigating how non-small cell lung cancer interacts with the immune system using humanized mouse models.

  This study is looking at how non-small cell lung cancer interacts with the immune system using special mice that have a human-like immune system, to help understand why some patients respond well to treatments while others don’t.

  NIH research Yale University · New Haven, United States · NIH-10683397

Related topics

Quick answers

How many Lung Cancer (NSCLC) clinical trials are recruiting right now?

58, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in China (23 trials), United States (13 trials), Italy (7 trials), Australia (3 trials), South Korea (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 14, Phase 1: 6, Phase 3: 2, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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