Understanding how lung cancer and immune cells influence each other in early lung cancer development
Official title: Spatial and temporal tumor-immune co-evolution and interactions that model lung adenocarcinoma development
Funded at University of Tx Md Anderson Can Ctr · NIH-11371145 · Data updated 2026-11-12
A study looks at how lung cells and immune cells change together as early lung cancer (lung adenocarcinoma) develops, with the goal of finding points to intervene early.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $408,178 |
| NIH project number | 5U01CA264583-05 |
| Project ID | NIH-11371145 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with lung adenocarcinoma or those at risk with available or accessible lung tissue samples may be eligible.
✕Less likely to help
Patients without LUAD or without access to relevant tissue samples may not benefit.
What this research studies
Researchers will study tissue samples from people with lung adenocarcinoma to map how epithelial cells and immune cells change in space and time during early tumor development. They will use advanced sequencing to compare multiple regions of the lung and build a picture of how cellular ecosystems and immune receptors evolve together in the cancer setting. This approach aims to identify early events and interactions that could be targeted to intercept cancer progression. The work could inform future strategies to detect, prevent, or treat LUAD at its earliest stages.
Why it matters
Potential benefit: If successful, the project could reveal new targets and timing for early interception or treatment of LUAD.
How similar studies have gone: Preliminary data show evolving cellular interactions in LUAD regions, suggesting this spatial approach is promising but still early.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Kadara, Humam — University of Tx Md Anderson Can Ctr
- Study coordinator: Kadara, Humam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.