Investigating how loss of a specific tumor suppressor affects lung cancer growth
Regulation of GLI1, a synthetic lethal target of SMARCA4-deficiency, in lung adenocarcinoma
This study is looking at how a missing protein called BRG1 affects a cancer-related gene called GLI1 in lung adenocarcinoma, with the goal of finding new treatment options for patients whose cancer is linked to the loss of BRG1.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11039974 on NIH RePORTER |
What this research studies
This research focuses on lung adenocarcinoma, particularly how the loss of the SMARCA4/BRG1 tumor suppressor influences the expression of GLI1, a transcription factor linked to poor survival outcomes. The study aims to understand the mechanisms by which BRG1 loss leads to increased GLI1 expression, which may drive cancer growth. By using genetic and pharmacological methods to inhibit GLI1, the researchers hope to find new therapeutic strategies for patients with BRG1-deficient lung cancer, a group currently lacking effective treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung adenocarcinoma who have mutations in the SMARCA4/BRG1 gene.
Not a fit: Patients with lung adenocarcinoma who do not have SMARCA4/BRG1 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with BRG1-deficient lung adenocarcinoma.
How similar studies have performed: While the specific approach of targeting GLI1 in BRG1-deficient lung cancer is novel, similar strategies targeting other pathways have shown promise in cancer treatment.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Kim, James — Ut Southwestern Medical Center
- Study coordinator: Kim, James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.