Investigating lymph node patterns in lung adenocarcinoma
Official title: Lymph Node Pathologic Grading Strategy: Under the Backdrop of the IASLC Grading System for Invasive Lung Adenocarcinoma - a Retrospective Cohort Study
Run by Fudan University · NCT06745830 · Data updated 2026-11-12
This study looks at how different patterns in lymph nodes from lung adenocarcinoma patients can help predict their health outcomes after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 2998 (estimated) |
| Sponsor | Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | April 10, 2024 |
| Main results expected | December 30, 2024 |
| Study ends | April 20, 2025 |
| Registry record updated | December 20, 2024 |
| Trial ID | NCT06745830 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with invasive lung adenocarcinoma who have undergone surgical resection.
✕Probably not a fit
Patients with adenocarcinoma in situ, minimally invasive adenocarcinoma, or other variants of adenocarcinoma may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the prognostic significance of pathologic patterns in metastatic lymph nodes (mLNs) of patients with lung adenocarcinoma. By analyzing a retrospective cohort of patients who underwent surgical resection, the study seeks to determine how the percentage of high-grade patterns in mLNs correlates with patient outcomes. The research focuses on understanding the implications of various histologic patterns in mLNs and their potential impact on prognosis.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of lung adenocarcinoma prognosis and improve patient management strategies.
How similar studies have gone: While the specific approach of this study may be novel, similar studies have explored the prognostic value of lymph node patterns in various cancers, indicating potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: From January 2011 to September 2021, we consecutively collected patients with invasive LUAD who underwent surgical resection at the Department of Thoracic Surgery, Fudan University Shanghai Cancer Center. Exclusion Criteria: 1. adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive mucinous adenocarcinoma, and other variants of adenocarcinoma; 2. incomplete common driver mutation data; 3. unavailable pathologic slides.
Where it's running
-
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Zhu
- Email: 20301050177@fudan.edu.cn
- Phone: 13301970795
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
DBC-664 in adults with solid tumors
A first-in-human study will test DBC-664 to see if it is safe and tolerable in adults with various advanced solid tumors and may hint at anti-tumor activity.
-
Ex Vivo Drug Response Testing in Lung Adenocarcinoma with Malignant Pleural Effusions
This study tests whether the way cancer cells from pleural effusions respond to drugs outside the body can predict how patients will respond to treatment.
-
Vortioxetine for cognitive problems in ALK/ROS1-positive NSCLC treated with lorlatinib
This observational study tests whether vortioxetine can help with cognitive and neurological side effects in adults with ALK/ROS1-positive NSCLC who are taking lorlatinib.
-
Targeted FSRT plus bevacizumab versus hippocampus-sparing whole-brain radiation for people with lung adenocarcinoma that has spread to the brain
This will test whether focused 5-day fractionated stereotactic radiotherapy (FSRT) combined with bevacizumab works better than hippocampus-avoidant whole-brain radiotherapy with a simultaneous boost at controlling brain metastases and protecting memory in adults with lung adenocarcinoma and extensive brain metastases.
-
7-day low-carb, high-fat (ketogenic) diet to improve FDG PET/CT detection of lepidic lung adenocarcinoma
This trial will test whether a personalized 7-day ketogenic (low-carb, high-fat) diet before an FDG PET/CT can improve detection of lepidic-predominant lung adenocarcinoma in adults with a suspicious lung nodule or confirmed diagnosis.
-
Partial high-dose tumor irradiation combined with immunotherapy for unresectable lung adenocarcinoma
This trial will try giving very high-dose radiation to the central part of large, unresectable lung adenocarcinomas while preserving the surrounding immune tissue and pairing that with an immune checkpoint drug for patients who have no remaining standard treatment options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.