Condition

Low-grade Glioma clinical trials and research

• 20Clinical trials
• 15NIH research projects
• 16Countries

Newest Low-grade Glioma clinical trials

All recruiting trials (20)

• Low-grade gliomas in Argentina: Incidence, survival, and treatment patterns

  This study tests how common low-grade gliomas are in Argentina and how long patients live after diagnosis, using two groups from Buenos Aires and Córdoba.

  Recruiting at 6 sites Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires F.D. and 5 other locations · NCT07631338

• Laser thermal therapy for young people with low-grade glioma

  This research will test whether laser interstitial thermal therapy (LITT) can stop or slow recurrent or progressive low-grade gliomas in children, adolescents, and young adults.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07506239

• Dabrafenib and trametinib dose-reduction for BRAF V600 low-grade glioma

  This trial tries to see if stopping or slowly lowering dabrafenib and trametinib after about 12–24 months works for people with BRAF V600–mutant low-grade glioma.

  Recruiting at 12 sites Phase 2 University of California, San Francisco · Birmingham, Alabama and 11 other locations · NCT07110246

• Home-based self-management and cognitive training for brain tumor survivors

  This trial will try a home-based cognitive coaching program to see if it improves thinking and quality of life for adults who survived non-glioblastoma brain tumors, with optional caregiver participation.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06930846

• Combining MAPK inhibitors with anti-PD1 therapy for pediatric gliomas with BRAF alterations

  This study is testing if combining two cancer drugs with a new therapy can help children with certain types of brain tumors feel better and have more treatment options.

  Recruiting Phase 1/2 Ann & Robert H Lurie Children's Hospital of Chicago · Washington D.C., District of Columbia and 2 other locations · NCT06712875

• Monitoring low-grade gliomas using blood samples

  This study is testing if analyzing blood samples can help monitor patients with low-grade brain tumors for signs of recurrence better than current MRI methods.

  Recruiting University Hospital, Caen · Caen · NCT06610851

• Combination treatment of vinblastine and tovorafenib for young patients with recurrent low-grade gliomas

  This study is testing a combination of two drugs, vinblastine and tovorafenib, to see if it can help young patients with recurring low-grade brain tumors feel better.

  Recruiting Early Phase 1 The Hospital for Sick Children · Toronto, Ontario · NCT06381570

• Using binimetinib for patients with specific types of brain and pancreatic cancer

  This study is testing if a medication called binimetinib can help people with specific types of brain and pancreatic cancer feel better and improve their condition.

  Recruiting at 6 sites Phase 2 National Cancer Center, Japan · Kashiwa, Chiba and 5 other locations · NCT06159478

• Dexamethasone dosing after brain tumor surgery

  This study is testing if a lower dose of dexamethasone after brain tumor surgery can help reduce side effects for patients compared to the usual dose.

  Recruiting Phase 2 Emory University · Atlanta, Georgia · NCT06132685

• Using MRI to evaluate low-grade brain tumors

  This study is testing a special type of MRI to see if it can help doctors better understand and predict how low-grade brain tumors in younger patients might change over time.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario and 1 other locations · NCT05996653

• Optimizing Proton Beam Treatment for Low Grade Glioma

  This study is testing a new way to plan proton beam treatment for people with low-grade glioma to see if it can improve results and reduce side effects compared to standard treatment.

  Recruiting Phase 2 University Hospital Heidelberg · Heidelberg · NCT05964569

• Evaluating a new imaging method for low-grade brain tumors in children

  This study is testing a new imaging method to see if it can help doctors better monitor and manage low-grade brain tumors in children.

  Recruiting Early Phase 1 Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT05555550

• Evaluating mirdametinib for low-grade glioma in young patients

  This study is testing a new drug called mirdametinib to see if it can safely help young patients with low-grade glioma feel better and live longer.

  Recruiting Phase 1/2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04923126

• Creating a living tissue bank from glioma tumors

  This study is trying to create mini versions of glioma tumors from patients to see how they behave and how different treatments might work better for people with glioma.

  Recruiting Maastricht Radiation Oncology · Maastricht, Limburg · NCT04865315

• Evaluating Tovorafenib for Pediatric Low-Grade Glioma and Advanced Solid Tumors

  This study is testing a new drug called Tovorafenib to see if it can help kids and young adults with certain brain tumors and advanced solid tumors feel better.

  Recruiting at 33 sites Phase 2 Day One Biopharmaceuticals, Inc. · San Francisco, California and 34 other locations · NCT04775485

• Using trametinib and everolimus to treat recurrent gliomas in children and young adults

  This study is testing a combination of two drugs, trametinib and everolimus, to see if they can safely help children and young adults with recurring brain tumors feel better and improve their quality of life.

  Recruiting at 15 sites Phase 1 University of California, San Francisco · Birmingham, Alabama and 16 other locations · NCT04485559

• Comparing radiotherapy alone to radiotherapy with temozolomide for treating high-risk low-grade gliomas after surgery

  This study is testing if adding a chemotherapy drug called temozolomide to radiotherapy helps people with high-risk low-grade brain tumors live longer and healthier after surgery.

  Recruiting Phase 2/3 West China Hospital · Chengdu, Sichuan · NCT04316039

• Comparing selumetinib to standard chemotherapy for low-grade glioma

  This study is testing if a new drug called selumetinib can help people with low-grade glioma live longer without their cancer getting worse compared to the usual chemotherapy.

  Recruiting at 124 sites Phase 3 National Cancer Institute (NCI) · Birmingham, Alabama and 131 other locations · NCT04166409

• Cognitive rehabilitation for adults with low-grade gliomas

  This study is testing if different types of cognitive rehabilitation, including an app and texting, can help adults with low-grade gliomas improve their thinking skills and quality of life.

  Recruiting University of California, San Francisco · San Francisco, California · NCT03948490

• Vaccine treatment for children with low-grade gliomas

  This study is testing a new vaccine treatment for children with hard-to-treat low-grade brain tumors to see if it can help their condition after they’ve already tried other treatments.

  Recruiting Phase 2 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT02358187

NIH-funded research (15)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• OPTIMUM: Engaging LGG patients in understanding how low-grade brain tumors evolve

  A large study plans to involve people with low-grade glioma to map how their tumors change from initial diagnosis to recurrence using patient-friendly data sharing and trial connections.

  NIH research Yale University · New Haven, United States · NIH-11421826

• Targeted therapies for pediatric low-grade glioma

  A pediatric brain tumor project aims to find better, safer targeted treatments for kids with low-grade gliomas.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11417209

• Understanding how diffuse low-grade gliomas disrupt cortical information processing

  This study looks at how a common adult brain tumor changes brain circuits and thinking skills, with the aim of guiding better therapies for cognitive problems.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11379967

• Targeting O-mannosylation in pediatric brain tumors driven by BRAF fusion

  A pediatric brain tumor project is exploring whether blocking a specific sugar-modifying process called POMT-mediated O-mannosylation can stop tumor growth in tumors driven by KIAA1549-BRAF fusions.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11366494

• Druggable targets in pediatric low-grade glioma through multi-modal data and screening

  A pediatric brain tumor study aims to find new drug targets by integrating imaging, genetics, and biology data to tailor treatments for children with low-grade gliomas.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11342859

• Improving patient participation to track how lower-grade brain tumors change over time

  This project works with adults who have lower-grade (WHO II/III) glioma to collect surgical tumor samples, medical records, and feedback so researchers can better understand how their tumors change from diagnosis to recurrence.

  NIH research Yale University · New Haven, United States · NIH-11194268

• Targeted treatments for childhood low-grade brain tumors

  Seeing if more precise RAF-targeting drugs and drug combinations can improve treatment for children with low-grade gliomas, especially tumors with BRAF changes.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11178583

• How the tumor neighborhood affects low-grade glioma turning into a more dangerous cancer

  Researchers will map cells and molecules inside low-grade glioma tumors to find signs that predict which tumors in people may become malignant.

  NIH research California Institute of Technology · Pasadena, United States · NIH-11174518

• How T cells affect low-grade brain tumors in children with NF1

  This project looks at how immune T cells and brain immune cells drive low-grade gliomas in children with Neurofibromatosis type 1 so safer, less toxic treatments might be found.

  NIH research Washington University · Saint Louis, United States · NIH-11145187

• How low-grade brain tumors disrupt the brain's information processing

  Researchers will learn how slow-growing (low-grade) gliomas change brain circuits and thinking in adults with these tumors.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11134644

• Exploring how the environment around low-grade gliomas affects their progression to cancer

  This study is looking at low-grade gliomas to find out why some of these brain tumors become more serious while others don’t, and it involves patients providing samples to help researchers create a detailed map that could lead to better ways to prevent tumor progression.

  NIH research California Institute of Technology · Pasadena, United States · NIH-10995229

• Improving patient involvement in understanding low grade brain tumors

  This study is all about helping young adults with low grade gliomas, a type of brain tumor, by creating a supportive community where they can share their experiences and medical information with researchers to better understand how these tumors change over time.

  NIH research Yale University · New Haven, United States · NIH-10927334

• Understanding how low-grade gliomas affect brain function

  This study is looking at how low-grade gliomas, a type of brain tumor, affect thinking and behavior in adults, and it hopes to find new ways to help improve brain function for those living with these tumors.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10923519

• How T cells influence low-grade brain tumors

  This study is looking at how certain immune cells called T cells affect the growth of brain tumors in kids with Neurofibromatosis type 1, using mice to learn more about how these cells work together, with the hope of finding better treatments for these tumors.

  NIH research Washington University · Saint Louis, United States · NIH-10902093

• Improving surgery for low-grade gliomas using advanced imaging techniques

  This study is testing a new way to help doctors see and remove low-grade brain tumors more effectively during surgery by using a special handheld microscope and a fluorescent dye, which could lead to better results and fewer chances of the tumor coming back.

  NIH research University of Washington · Seattle, United States · NIH-10843872

Related topics

Quick answers

How many Low-grade Glioma clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (12 trials), Canada (4 trials), Germany (2 trials), Netherlands (2 trials), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 2, Early Phase 1: 2, Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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