Exploring how the environment around low-grade gliomas affects their progression to cancer
Understanding the role of tumor microenvironment in low grade glioma progression to malignancy
This study is looking at low-grade gliomas to find out why some of these brain tumors become more serious while others don’t, and it involves patients providing samples to help researchers create a detailed map that could lead to better ways to prevent tumor progression.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10995229 on NIH RePORTER |
What this research studies
This research investigates the tumor microenvironment of low-grade gliomas to understand why some tumors progress to malignancy while others remain stable. By collaborating with experts from UCLA and Caltech, the team will create a detailed atlas comparing different glioma samples using advanced techniques like spatial transcriptomics and proteomics. The goal is to identify molecular and cellular changes that predict malignant transformation, which could lead to new strategies for prevention. Patients will contribute fresh samples to help build this comparative atlas and enhance our understanding of glioma behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with low-grade gliomas, particularly those from diverse backgrounds.
Not a fit: Patients with high-grade gliomas or those who do not have gliomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that prevent low-grade gliomas from becoming malignant.
How similar studies have performed: Other research has shown promise in understanding tumor microenvironments, suggesting that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Cai, Long — California Institute of Technology
- Study coordinator: Cai, Long
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.