Using MRI to evaluate low-grade brain tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project focuses on low-grade gliomas, which are malignant brain tumors that often affect younger individuals. The study utilizes a non-contrast metabolic MRI technique called Saturation Transfer (ST)-MRI to assess tumor progression and predict early changes in these tumors. By identifying patients whose tumors are likely to progress, the study aims to enable timely interventions. The ST-MRI method provides metabolic information that standard MRI cannot capture, enhancing the understanding of tumor behavior without the need for contrast agents.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Be at least 12 years of age;
2. Diagnosed with:

   1. Cohort A (pre-surgical): Suspected LGG (oligodendroglioma or astrocytoma), based on any combination of histological, molecular, radiological, and/or clinical findings; or
   2. Cohort B (post-surgical): IDH1/2-mutant or IDH-wildtype (WT) low-grade glioma candidate for observation
3. No contraindications to MRI;
4. eGFR \> 30 ml/min;
5. No prior chemotherapy or radiation therapy;
6. No need for upfront treatment (surgery, chemotherapy, and/or radiation therapy)
7. Followed at either Sunnybrook Health Sciences Centre or at St Michael's Hospital

Exclusion Criteria:

1. Need for upfront post-surgical treatment with either chemotherapy and/or radiation therapy
2. Pregnancy

Where it's running

• Sunnybrook Health Sciences Centre
  Toronto, Ontario, Canada Recruiting
• St. Michael's Hospital
  Toronto, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Greg J Stanisz, PhD — Sunnybrook Health Sciences Centre
• Study coordinator: Mary Jane Lim-Fat, MD
• Email: MaryJane.LimFat@sunnybrook.ca
• Phone: 416-480-6100

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Monitoring low-grade gliomas using blood samples

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.