Low-grade gliomas in Argentina: Incidence, survival, and treatment patterns

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective, multicenter observational study in Argentina with two cohorts. Cohort 1 estimates LGG incidence density in adults enrolled in the Hospital Italiano de Buenos Aires Health Plan from 2011 to 2023. Cohort 2 analyzes survival outcomes (OS and DFS at 1 and 5 years) for histologically confirmed LGG patients treated at participating centers. Data are collected in a centralized REDCap database and analyzed to describe therapeutic strategies, molecular profiles, and prognostic factors using Kaplan-Meier estimates and multivariable Cox regression. The study aims to fill gaps in LGG incidence and survival data for a middle-income country setting, with emphasis on molecular markers such as IDH status and 1p/19q codeletion where available.

Why it matters

Who can join: the full rules

Study population cohort 1

* Inclusion Criteria

  * Adult patients (≥18 years old) affiliated to the health plan of Hospital Italiano de Buenos Aires.
  * Documented clinical follow-up of at least 1 year during the study period.
* Exclusion Criteria

  * Patients not affiliated to the health plan of the Hospital Italiano de Buenos Aires.

Study population cohort 2

* Inclusion Criteria

  * Adult patients (≥18 years) with histopathologically confirmed diagnosis of low-grade glioma (WHO grades I and II).
* Exclusion Criteria

  * Incomplete or doubtful diagnosis based on histopathologic and molecular criteria.

Where it's running

• Hospital Alemán
  Buenos Aires, Buenos Aires F.D., Argentina Recruiting
• Hospital Italiano de Buenos Aires
  Buenos Aires, Buenos Aires F.D., Argentina Recruiting
• Hospital Privado Universitario de Córdoba
  Córdoba, Córdoba Province, Argentina Recruiting
• Hospital de Alta Complejidad El Cruce - Dr. Néstor Kirchner
  Buenos Aires, Florencio Varela, Argentina Recruiting
• Hospital Universitario Austral
  Buenos Aires, Pilar, Argentina Recruiting
• Hospital Italiano sede San Justo Agustín Rocca
  Buenos Aires, San Justo, Argentina Recruiting

Study contacts

• Study coordinator: Ivan Alfredo Huespe, MD, MPh
• Email: ivan.huespe@hospitalitaliano.org.ar
• Phone: +5493425382554

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.