Improving surgery for low-grade gliomas using advanced imaging techniques
In vivo dual-axis confocal microscopy of 5-ALA-induced PpIX to guide low-grade glioma resections
This study is testing a new way to help doctors see and remove low-grade brain tumors more effectively during surgery by using a special handheld microscope and a fluorescent dye, which could lead to better results and fewer chances of the tumor coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10843872 on NIH RePORTER |
What this research studies
This research focuses on enhancing the surgical removal of low-grade gliomas by using a specialized imaging technique called dual-axis confocal microscopy. By utilizing a fluorescent agent known as 5-ALA, the study aims to improve the visualization of tumor margins during surgery, allowing surgeons to detect and remove more cancerous cells. The approach involves optimizing a handheld microscope that can provide high-resolution images in real-time, which could lead to better surgical outcomes and reduced recurrence rates for patients. The research seeks to address the limitations of current imaging methods that may miss infiltrative tumor cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with low-grade gliomas who are scheduled for surgical resection.
Not a fit: Patients with high-grade gliomas or those not undergoing surgical treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more complete tumor removals and improved survival rates for patients with low-grade gliomas.
How similar studies have performed: Previous research has shown promising results with fluorescence-guided surgery, but this specific approach using dual-axis confocal microscopy is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Liu, Jonathan T.c. — University of Washington
- Study coordinator: Liu, Jonathan T.c.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.