How T cells influence low-grade brain tumors
T Cell Regulation of Low-Grade Glioma
This study is looking at how certain immune cells called T cells affect the growth of brain tumors in kids with Neurofibromatosis type 1, using mice to learn more about how these cells work together, with the hope of finding better treatments for these tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10902093 on NIH RePORTER |
What this research studies
This research investigates the role of T cells in the development and growth of low-grade gliomas, particularly in children with Neurofibromatosis type 1 (NF1). The study uses mouse models to explore how NF1-mutant neurons interact with T cells and other immune cells to promote tumor growth. By understanding these interactions, the research aims to identify new therapeutic strategies that could improve treatment outcomes for patients with these brain tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with low-grade gliomas, especially those with Neurofibromatosis type 1.
Not a fit: Patients with high-grade gliomas or those without a diagnosis of Neurofibromatosis type 1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for low-grade gliomas, reducing long-term health issues for affected children.
How similar studies have performed: Other research has shown promising results in understanding the immune system's role in tumor growth, making this approach both relevant and potentially impactful.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gutmann, David H — Washington University
- Study coordinator: Gutmann, David H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.