How T cells influence low-grade brain tumors
Official title: T Cell Regulation of Low-Grade Glioma
Funded at Washington University · NIH-10902093 · Data updated 2026-11-12
This study is looking at how certain immune cells called T cells affect the growth of brain tumors in kids with Neurofibromatosis type 1, using mice to learn more about how these cells work together, with the hope of finding better treatments for these tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 9, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $440,179 |
| NIH project number | 5R01CA261939-03 |
| Project ID | NIH-10902093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with low-grade gliomas, especially those with Neurofibromatosis type 1.
✕Less likely to help
Patients with high-grade gliomas or those without a diagnosis of Neurofibromatosis type 1 may not benefit from this research.
What this research studies
This research investigates the role of T cells in the development and growth of low-grade gliomas, particularly in children with Neurofibromatosis type 1 (NF1). The study uses mouse models to explore how NF1-mutant neurons interact with T cells and other immune cells to promote tumor growth. By understanding these interactions, the research aims to identify new therapeutic strategies that could improve treatment outcomes for patients with these brain tumors.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for low-grade gliomas, reducing long-term health issues for affected children.
How similar studies have gone: Other research has shown promising results in understanding the immune system's role in tumor growth, making this approach both relevant and potentially impactful.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Gutmann, David H — Washington University
- Study coordinator: Gutmann, David H
Related research
Other NIH-funded projects on the same topics.
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OPTIMUM: Engaging LGG patients in understanding how low-grade brain tumors evolve
A large study plans to involve people with low-grade glioma to map how their tumors change from initial diagnosis to recurrence using patient-friendly data sharing and trial connections.
-
Targeted therapies for pediatric low-grade glioma
A pediatric brain tumor project aims to find better, safer targeted treatments for kids with low-grade gliomas.
-
Understanding how diffuse low-grade gliomas disrupt cortical information processing
This study looks at how a common adult brain tumor changes brain circuits and thinking skills, with the aim of guiding better therapies for cognitive problems.
-
Targeting O-mannosylation in pediatric brain tumors driven by BRAF fusion
A pediatric brain tumor project is exploring whether blocking a specific sugar-modifying process called POMT-mediated O-mannosylation can stop tumor growth in tumors driven by KIAA1549-BRAF fusions.
-
Druggable targets in pediatric low-grade glioma through multi-modal data and screening
A pediatric brain tumor study aims to find new drug targets by integrating imaging, genetics, and biology data to tailor treatments for children with low-grade gliomas.
-
Improving patient participation to track how lower-grade brain tumors change over time
This project works with adults who have lower-grade (WHO II/III) glioma to collect surgical tumor samples, medical records, and feedback so researchers can better understand how their tumors change from diagnosis to recurrence.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.