Improving patient involvement in understanding low grade brain tumors
Official title: OPTimIzing engageMent in discovery of molecular evolution of low grade glioma (OPTIMUM)
Funded at Yale University · NIH-10927334 · Data updated 2026-11-12
This study is all about helping young adults with low grade gliomas, a type of brain tumor, by creating a supportive community where they can share their experiences and medical information with researchers to better understand how these tumors change over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 21, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $771,769 |
| NIH project number | 5U2CCA252979-04 |
| Project ID | NIH-10927334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with low grade gliomas who have undergone surgical resection and are willing to participate in genomic studies.
✕Less likely to help
Patients with other types of brain tumors or those who have not had surgery for low grade gliomas may not benefit from this research.
What this research studies
This research focuses on low grade gliomas, a type of brain tumor that primarily affects young adults. It aims to enhance patient engagement in genomic studies that track the evolution of these tumors from diagnosis to recurrence. By building a community of 700 patients who have had surgery for their tumors, the project will utilize both in-person and online methods to facilitate communication and data sharing between patients and researchers. The study will leverage existing tools to ensure patients can easily access and share their medical records, thereby improving their participation and satisfaction in the research process.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of low grade gliomas, ultimately improving outcomes for patients.
How similar studies have gone: Previous research has shown success in patient engagement strategies for genomic studies, indicating that this approach has potential for meaningful impact.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Claus, Elizabeth B. — Yale University
- Study coordinator: Claus, Elizabeth B.
Related research
Other NIH-funded projects on the same topics.
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OPTIMUM: Engaging LGG patients in understanding how low-grade brain tumors evolve
A large study plans to involve people with low-grade glioma to map how their tumors change from initial diagnosis to recurrence using patient-friendly data sharing and trial connections.
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Targeted therapies for pediatric low-grade glioma
A pediatric brain tumor project aims to find better, safer targeted treatments for kids with low-grade gliomas.
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Understanding how diffuse low-grade gliomas disrupt cortical information processing
This study looks at how a common adult brain tumor changes brain circuits and thinking skills, with the aim of guiding better therapies for cognitive problems.
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Targeting O-mannosylation in pediatric brain tumors driven by BRAF fusion
A pediatric brain tumor project is exploring whether blocking a specific sugar-modifying process called POMT-mediated O-mannosylation can stop tumor growth in tumors driven by KIAA1549-BRAF fusions.
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Druggable targets in pediatric low-grade glioma through multi-modal data and screening
A pediatric brain tumor study aims to find new drug targets by integrating imaging, genetics, and biology data to tailor treatments for children with low-grade gliomas.
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Improving patient participation to track how lower-grade brain tumors change over time
This project works with adults who have lower-grade (WHO II/III) glioma to collect surgical tumor samples, medical records, and feedback so researchers can better understand how their tumors change from diagnosis to recurrence.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.