Cognitive rehabilitation for adults with low-grade gliomas

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of cognitive rehabilitation therapy in improving cognitive function in patients with low-grade gliomas, who often experience cognitive impairments affecting their daily lives. The study utilizes various methods, including an iPad app called ReMind, healthy SMS texting, in-person cognitive rehabilitation, and telehealth cognitive rehabilitation. The primary objectives include assessing the feasibility of these interventions and measuring cognitive decline over a 36-month follow-up period. Secondary objectives focus on changes in cognition and health-related quality of life at multiple time points post-intervention.

Why it matters

Who can join: the full rules

Arm 1:

Inclusion Criteria:

* Histologically confirmed low grade supratentorial primary brain tumor
* \>= 18 years old
* Life expectancy \> 12 weeks
* Karnofsky performance status (KPS) \>= 70
* Must speak and be able to read English fluently
* Must have access to the internet
* Must have text enabled cellphone
* Must be receiving MRI scans at University of California, San Francisco (UCSF)
* Must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 3 months
* Must be \>= 6 months from craniotomy
* Must have subjective complaints of cognitive deficits
* Must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics
* Must score \<= 1 SD below normal on ≥ 2 or more domains of baseline neuropsychological assessments

Exclusion Criteria:

* Diagnosis or evidence of any of the following:
* • Glioblastoma
* • Extra-axial disease (i.e. meningioma)
* • Infra-tentorial disease
* Are not able to comply with study and/or follow-up procedures
* Are unable to complete or score \>= 3 cognitive tests at baseline, which is indicative that patients would be unable to complete the cognitive rehabilitation interventions
* Are acutely suicidal, psychotic, and/or gravely disabled.
* Patients who, based on the neuropsychologist's opinion, are unable to participate in cognitive testing and/or cognitive rehab secondary to significant neurologic deficit

Arm 2:

Inclusion Criteria:

* Have a presumed lower grade IDH-mutated primary brain tumor and either be undergoing definitive surgery or have had surgical resection within the last 4 months.
* Prior surgery is allowed if they have not received additional tumor directed treatment.
* \>= 18 years old
* Must speak and be able to read English fluently.
* Plan to continue to care in neuro-oncology at UCSF
* Must be receiving MRI scans.

Exclusion Criteria:

* Diagnosis or evidence of any of the following:
* • Primary brain tumor classified as CNS WHO Grade 4
* • Extra-axial disease (i.e. meningioma)
* Are not able to comply with study and/or follow-up procedures
* Have acute psychiatric issues (suicidality, active psychosis, gravely disabled)

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Jennie Taylor, MD, MPH — University of California, San Francisco
• Study coordinator: Jennie Taylor, MD, MPH
• Email: jennie.taylor@ucsf.edu
• Phone: 415-353-2966

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.