Improving patient participation to track how lower-grade brain tumors change over time
OPTimIzing engageMent in discovery of molecular evolution of low grade glioma (OPTIMUM)
This project works with adults who have lower-grade (WHO II/III) glioma to collect surgical tumor samples, medical records, and feedback so researchers can better understand how their tumors change from diagnosis to recurrence.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11194268 on NIH RePORTER |
What this research studies
If you join, you'll become part of an international community of up to 700 people with lower-grade glioma who had surgery at diagnosis and again at recurrence. The team will collect and link your medical records and tumor samples and use secure platforms (HUGO PHR) to let you control and share data and ARCHETYP to help find clinical trials. Researchers will perform genomic analyses comparing primary and recurrent tumors to map molecular evolution. Engagement happens through hospitals and web/social media so you can receive study updates and communicate with the team.
Who could benefit from this research
Good fit: Adults with WHO grade II or III glioma who had surgical resection at diagnosis and again at recurrence and who are willing to share medical records and tumor tissue are ideal candidates.
Not a fit: People without available surgical tissue from both diagnosis and recurrence, or those unwilling or unable to share records or participate online, may not be eligible or benefit.
Why it matters
Potential benefit: This could help doctors learn how low-grade gliomas evolve and guide future treatments and trial options for patients.
How similar studies have performed: Previous genomic studies have described glioma changes over time, but assembling large numbers of paired primary-and-recurrent samples linked to patient engagement platforms is a newer approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Claus, Elizabeth B. — Yale University
- Study coordinator: Claus, Elizabeth B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.