Understanding how low-grade gliomas affect brain function
Cortical information loss in diffuse low-grade glioma infiltrated cortex
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10923519
This study is looking at how low-grade gliomas, a type of brain tumor, affect thinking and behavior in adults, and it hopes to find new ways to help improve brain function for those living with these tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10923519 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of low-grade gliomas, a common type of brain tumor, on cognitive and behavioral functions in adults. It aims to uncover how these tumors infiltrate healthy brain tissue and alter the interactions between neurons that are crucial for processing information. By studying the cellular and circuit-level mechanisms involved, the research seeks to identify new therapeutic approaches to mitigate cognitive impairments associated with gliomas. Patients may be involved in clinical trials that explore innovative treatments targeting these disruptions in brain function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with low-grade gliomas who are experiencing cognitive and behavioral impairments.
Not a fit: Patients with high-grade gliomas or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new precision-medicine therapies that improve cognitive function in patients with low-grade gliomas.
How similar studies have performed: Previous research has shown promise in understanding the effects of brain tumors on cognitive function, but this specific approach to studying low-grade gliomas is relatively novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HERVEY-JUMPER, SHAWN L. — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: HERVEY-JUMPER, SHAWN L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.