Understanding how low-grade gliomas affect brain function
Official title: Cortical information loss in diffuse low-grade glioma infiltrated cortex
Funded at University of California, San Francisco · NIH-10923519 · Data updated 2026-11-12
This study is looking at how low-grade gliomas, a type of brain tumor, affect thinking and behavior in adults, and it hopes to find new ways to help improve brain function for those living with these tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 9, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $416,265 |
| NIH project number | 1R01NS137950-01 |
| Project ID | NIH-10923519 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with low-grade gliomas who are experiencing cognitive and behavioral impairments.
✕Less likely to help
Patients with high-grade gliomas or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the impact of low-grade gliomas, a common type of brain tumor, on cognitive and behavioral functions in adults. It aims to uncover how these tumors infiltrate healthy brain tissue and alter the interactions between neurons that are crucial for processing information. By studying the cellular and circuit-level mechanisms involved, the research seeks to identify new therapeutic approaches to mitigate cognitive impairments associated with gliomas. Patients may be involved in clinical trials that explore innovative treatments targeting these disruptions in brain function.
Why it matters
Potential benefit: If successful, this research could lead to new precision-medicine therapies that improve cognitive function in patients with low-grade gliomas.
How similar studies have gone: Previous research has shown promise in understanding the effects of brain tumors on cognitive function, but this specific approach to studying low-grade gliomas is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Hervey-Jumper, Shawn L. — University of California, San Francisco
- Study coordinator: Hervey-Jumper, Shawn L.
Related research
Other NIH-funded projects on the same topics.
-
OPTIMUM: Engaging LGG patients in understanding how low-grade brain tumors evolve
A large study plans to involve people with low-grade glioma to map how their tumors change from initial diagnosis to recurrence using patient-friendly data sharing and trial connections.
-
Targeted therapies for pediatric low-grade glioma
A pediatric brain tumor project aims to find better, safer targeted treatments for kids with low-grade gliomas.
-
Understanding how diffuse low-grade gliomas disrupt cortical information processing
This study looks at how a common adult brain tumor changes brain circuits and thinking skills, with the aim of guiding better therapies for cognitive problems.
-
Targeting O-mannosylation in pediatric brain tumors driven by BRAF fusion
A pediatric brain tumor project is exploring whether blocking a specific sugar-modifying process called POMT-mediated O-mannosylation can stop tumor growth in tumors driven by KIAA1549-BRAF fusions.
-
Druggable targets in pediatric low-grade glioma through multi-modal data and screening
A pediatric brain tumor study aims to find new drug targets by integrating imaging, genetics, and biology data to tailor treatments for children with low-grade gliomas.
-
Improving patient participation to track how lower-grade brain tumors change over time
This project works with adults who have lower-grade (WHO II/III) glioma to collect surgical tumor samples, medical records, and feedback so researchers can better understand how their tumors change from diagnosis to recurrence.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.