Investigating how specific signaling pathways affect liver fibrosis
Role of SMAD1/5/8 signaling in liver fibrosis
This study is looking at how certain signals in the liver can affect the health of liver cells and contribute to conditions like hemochromatosis and NASH, with the goal of finding new ways to help treat liver fibrosis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11144567 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of SMAD1/5/8 signaling pathways in liver fibrosis, particularly how they affect the activation of hepatic stellate cells (HSCs). The study will utilize both laboratory and animal models to explore how these pathways influence liver health, especially in conditions like hemochromatosis and non-alcoholic steatohepatitis (NASH). By examining the mechanisms of these signaling pathways, the research aims to uncover potential therapeutic targets for treating liver fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from liver fibrosis or related conditions, particularly those with alcohol-related liver disease or NASH.
Not a fit: Patients with liver fibrosis due to non-alcoholic causes unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse liver fibrosis, improving outcomes for patients with liver diseases.
How similar studies have performed: Previous research has shown promising results in targeting similar signaling pathways for liver diseases, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Xiao, Xia — Massachusetts General Hospital
- Study coordinator: Xiao, Xia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.