How blood clotting affects liver scarring
Official title: Novel mechanisms linking blood coagulation to liver fibrosis
Funded at Rutgers Biomedical and Health Sciences · NIH-11207318 · Data updated 2026-11-12
This study is looking at how certain proteins in your blood that help with clotting might affect liver damage and scarring, with the hope of finding new ways to treat liver diseases for people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $98,629 |
| NIH project number | 3R00DK129710-05S1 |
| Project ID | NIH-11207318 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic liver injury or conditions that may lead to liver fibrosis.
✕Less likely to help
Patients with acute liver injury or those without any liver-related conditions may not benefit from this research.
What this research studies
This research investigates the role of blood coagulation factors in the signaling processes that occur during liver injury and inflammation. It aims to understand how the activation of specific receptors by blood clotting proteins can lead to liver scarring, a condition known as hepatic fibrosis. By exploring the mechanisms involved, the research seeks to uncover new insights that could lead to better treatments for liver diseases. Patients may benefit from this research as it could identify new therapeutic targets for managing liver fibrosis.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce liver scarring in patients with liver diseases.
How similar studies have gone: Other research has shown promising results in understanding the role of blood coagulation in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Poole, Lauren G — Rutgers Biomedical and Health Sciences
- Study coordinator: Poole, Lauren G
Related research
Other NIH-funded projects on the same topics.
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Role of SMAD1/5/8 signaling in liver fibrosis
This grant explores how specific liver cell signals influence scarring (fibrosis) in the liver, with a focus on people who have alcohol-related liver disease or related conditions.
-
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A study to test a new peptide that blocks a key fibrosis signal and a gene-silencing approach to help reverse liver fibrosis caused by alcohol use.
-
Understanding how RNA binding proteins drive liver scarring and how to slow it down
A researcher team is studying how certain RNA binding proteins, especially LARP6, regulate the liver’s scar-building process in alcoholic liver disease to identify potential ways to reduce fibrosis.
-
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Affects people with MASLD/MASH may benefit from a better understanding of how certain immune cells contribute to liver fibrosis and how to stop it.
-
Liver fibrosis test platform using patient-derived liver tissue to speed anti-fibrosis drugs
A patient-focused liver fibrosis test platform is being developed to help speed the creation of medicines that treat liver scarring by using human-derived liver cells and tissue signals.
-
Role of HK2 in liver scarring, fatty liver disease, and liver cancer
A study in adults looks at how the enzyme HK2 helps drive liver scarring in NASH and may influence the development of liver cancer, with potential to point to new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.