Understanding how liver fibrosis develops
Official title: Pathobiology of liver fibrosis
Funded at Mayo Clinic Rochester · NIH-11085291 · Data updated 2026-11-12
This study is looking into how a protein called PDGF helps cause liver fibrosis, which can lead to serious liver problems, and aims to find new ways to treat or even reverse this condition to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $355,080 |
| NIH project number | 5R01DK136511-03 |
| Project ID | NIH-11085291 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with liver fibrosis or at risk of developing liver-related complications.
✕Less likely to help
Patients with early-stage liver disease or those without significant fibrosis may not benefit from this research.
What this research studies
This research investigates the mechanisms behind liver fibrosis, a serious condition that can lead to cirrhosis and liver failure. The team will explore how certain signals, particularly from a protein called platelet-derived growth factor (PDGF), contribute to the activation of liver cells that promote fibrosis. By using advanced cellular and animal models, the researchers aim to identify potential new treatment strategies that could halt or reverse the progression of liver fibrosis. Patients may benefit from insights gained that could lead to innovative therapies for this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver fibrosis, potentially improving outcomes for patients with liver disease.
How similar studies have gone: Previous research has shown promising results in understanding liver fibrosis mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kostallari, Enis — Mayo Clinic Rochester
- Study coordinator: Kostallari, Enis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.