Understanding how blood clotting affects liver scarring
Official title: Novel mechanisms linking blood coagulation to liver fibrosis
Funded at Rutgers Biomedical and Health Sciences · NIH-10976425 · Data updated 2026-11-12
This study is looking at how certain blood clotting factors affect liver injury and inflammation, with the hope of finding new ways to help people with liver diseases like fibrosis, which causes scarring in the liver.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | January 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $236,166 |
| NIH project number | 5R00DK129710-05 |
| Project ID | NIH-10976425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic liver conditions or those at risk of developing liver fibrosis.
✕Less likely to help
Patients with acute liver injuries unrelated to coagulation factors may not benefit from this research.
What this research studies
This research investigates the role of blood coagulation factors in the signaling processes that occur during liver injury and inflammation. It aims to uncover how the activation of specific receptors by coagulation factors can lead to the development of liver fibrosis, a condition characterized by scarring of the liver. By exploring the mechanisms involved, the research seeks to provide insights that could lead to new therapeutic strategies for liver diseases. Patients may benefit from a better understanding of how their liver conditions are influenced by blood clotting.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver fibrosis, improving outcomes for patients with chronic liver diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of blood coagulation in liver diseases, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Poole, Lauren G — Rutgers Biomedical and Health Sciences
- Study coordinator: Poole, Lauren G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.