Understanding how liver cells contribute to fibrosis
Molecular Mechanisms of Liver Fibrosis
This study is looking at how a protein called synectin affects certain liver cells that play a role in liver scarring, with the hope of finding new treatments for people with liver fibrosis and cirrhosis.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11087515 on NIH RePORTER |
What this research studies
This research investigates the role of hepatic stellate cells (HSCs) in the development of liver fibrosis, particularly focusing on a protein called synectin that influences HSC migration and activation. By studying how synectin affects cell behavior and gene expression, the researchers aim to uncover potential therapeutic targets for treating cirrhosis. The approach includes both laboratory experiments and analysis of human tissue samples to understand the molecular mechanisms involved. Patients may benefit from insights that could lead to new treatments for liver fibrosis and cirrhosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with liver fibrosis or cirrhosis, particularly those with a history of alcohol consumption.
Not a fit: Patients with liver conditions unrelated to fibrosis or cirrhosis may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse liver fibrosis, improving outcomes for patients with liver disease.
How similar studies have performed: Other research has shown promising results in targeting cellular mechanisms in liver fibrosis, suggesting that this approach could be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Shah, Vijay H. — Mayo Clinic Rochester
- Study coordinator: Shah, Vijay H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.