Investigating the role of CYP1B1 in liver fibrosis
Official title: Cellular and Metabolic Basis of the Role of CYP1B1 in Liver Fibrosis
Funded at University of Pittsburgh at Pittsburgh · NIH-11058420 · Data updated 2026-11-12
This study is looking at how a certain enzyme called CYP1B1 affects liver fibrosis, a condition that can happen after long-term liver damage, and aims to find new ways to help treat it by understanding how liver cells work together during this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $375,099 |
| NIH project number | 5R01DK135538-03 |
| Project ID | NIH-11058420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic liver injury or liver fibrosis.
✕Less likely to help
Patients with acute liver injury or those without liver fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding how a specific enzyme, CYP1B1, contributes to liver fibrosis, a condition often resulting from chronic liver injury. The study aims to explore the activation of hepatic stellate cells (HSCs), which are crucial in the development of liver fibrosis. By examining the molecular mechanisms behind HSC activation and the role of CYP1B1, researchers hope to identify new therapeutic strategies for treating liver fibrosis. The approach includes analyzing cell types in the liver and how they interact with CYP1B1 during fibrosis progression.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for liver fibrosis, potentially improving outcomes for patients with chronic liver disease.
How similar studies have gone: While the specific role of CYP1B1 in liver fibrosis is not well-established, similar studies have shown promise in understanding the mechanisms of liver diseases and developing targeted therapies.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Xie, Wen — University of Pittsburgh at Pittsburgh
- Study coordinator: Xie, Wen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.