Condition

Metabolic Dysfunction-Associated Steatohepatitis (MASH) clinical trials and research

• 9Clinical trials
• 41Countries

Newest Metabolic Dysfunction-Associated Steatohepatitis (MASH) clinical trials

All recruiting trials (9)

• Pemvidutide for noncirrhotic MASH: a phase 3 study

  This phase 3 study tests pemvidutide versus placebo in adults with noncirrhotic MASH to see if it improves liver health and safety.

  Recruiting at 9 sites Phase 3 Altimmune, Inc. · North Little Rock, Arkansas and 8 other locations · NCT07795164

• VV-14303 for metabolic liver disease in adults with MASH

  This study tests VV-14303, a gene therapy, in adults with metabolic dysfunction-associated steatohepatitis (MASH) to see if it is safe and how well it works.

  Recruiting Phase 1/2 Kriya Therapeutics, Inc. · Chandler, Arizona and 2 other locations · NCT07732400

• HRS-4729 and HRS9531 injections in adults with MASH

  This study tests whether HRS-4729 and HRS9531 injections (and their placebos) can help adults with metabolic dysfunction-associated steatohepatitis after 52 weeks of treatment.

  Recruiting at 2 sites Phase 2 Fujian Shengdi Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality and 1 other locations · NCT07660848

• Gut microbiota–derived amino acid metabolites in MASLD/MASH

  This study tests whether gut microbiota–produced amino acid metabolites are linked to MASLD/MASH in adults by collecting stool, blood, and urine samples and analyzing dietary factors.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT07313007

• Patients' perspectives and needs in metabolic dysfunction‑associated steatohepatitis

  This study will see what adults with MASH expect, need, and feel about their care before and after taking part in a cardiovascular health program in Barcelona.

  Recruiting at 2 sites Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona and 1 other locations · NCT07188220

• UBT251 treatment for metabolic dysfunction-associated steatohepatitis (MASH)

  This trial will test whether daily UBT251 (2 mg, 4 mg, or 6 mg) for 48 weeks helps adults with biopsy-confirmed MASH and moderate fibrosis compared with placebo.

  Recruiting Phase 2 The United Bio-Technology (Hengqin) Co., Ltd. · Beijing, Beijing Municipality · NCT07145151

• Testing Survodutide for Liver Disease in Patients with NASH/MASH

  This study is testing a new medication called survodutide to see if it can help adults with liver disease related to metabolic dysfunction feel better and improve their liver health.

  Recruiting at 497 sites Phase 3 Boehringer Ingelheim · Birmingham, Alabama and 531 other locations · NCT06632444

• Improving liver health through metabolic surgery or medication

  This study is testing whether metabolic surgery or medication can improve liver health in people with liver disease and obesity.

  Recruiting at 2 sites Phase 4 The Cleveland Clinic · Phoenix, Arizona and 21 other locations · NCT06374875

• Gene silencing treatment for chronic liver disease in genetically at-risk adults

  This study is testing a new drug to see if it can help adults at higher genetic risk for liver disease by reducing liver damage and inflammation.

  Recruiting at 36 sites Phase 2 Regeneron Pharmaceuticals · Flagstaff, Arizona and 70 other locations · NCT05519475

Related topics

Quick answers

How many Metabolic Dysfunction-Associated Steatohepatitis (MASH) clinical trials are recruiting right now?

9, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 41 countries. The most sites are in United States (4 trials), Spain (3 trials), China (3 trials), New Zealand (2 trials), Brazil (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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