Investigating how mitochondrial signals contribute to liver fibrosis in NASH
Official title: Mitochondrial DAMPs-driven Mechanisms of Liver Fibrosis in NASH
Funded at Beth Israel Deaconess Medical Center · NIH-11049185 · Data updated 2026-11-12
This study is looking at how changes in the tiny energy factories in your cells, called mitochondria, might affect the worsening of liver problems in people with non-alcoholic steatohepatitis (NASH), and it hopes to find new ways to help protect your liver.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $614,322 |
| NIH project number | 5R01DK139288-02 |
| Project ID | NIH-11049185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis (NASH) who may be experiencing liver fibrosis.
✕Less likely to help
Patients with liver conditions unrelated to NASH or those without significant liver damage may not benefit from this research.
What this research studies
This research focuses on understanding the role of mitochondrial DNA in the progression of non-alcoholic steatohepatitis (NASH), a serious liver condition. Researchers will explore how damaged mitochondria release signals that may trigger liver fibrosis, using advanced assays to measure mitochondrial DNA in blood samples. By studying these mechanisms, the research aims to uncover potential therapeutic targets for preventing or treating liver damage in patients with NASH.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse liver fibrosis in patients with NASH.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial roles in liver diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Popov, Yury — Beth Israel Deaconess Medical Center
- Study coordinator: Popov, Yury
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.