A model to understand and treat liver fibrosis
A Model for Human Liver Fibrosis
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-10685178
This study is exploring new ways to treat liver fibrosis, a serious condition affecting the liver, by using tiny lab-grown liver models to test how well different drugs can help reduce the damage and improve health for people with liver diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10685178 on ClinicalTrials.gov |
What this research studies
This research focuses on liver fibrosis, a serious condition caused by the buildup of extracellular matrix in the liver due to chronic injury. The team has developed human liver organoid models that mimic the disease, allowing for detailed study of how fibrosis develops and how it can be treated. By using these organoids, researchers can test new drug candidates and observe their effects on collagen production and fibrosis progression. This innovative approach aims to provide insights into effective therapies for patients suffering from liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from liver fibrosis or related liver diseases, particularly those with conditions like viral-induced cirrhosis or non-alcoholic steatohepatitis (NASH).
Not a fit: Patients with acute liver injuries or those without chronic liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver fibrosis, improving outcomes for patients with liver diseases.
How similar studies have performed: Previous research has shown promise in using organoid models for studying various diseases, indicating that this approach could yield valuable insights into liver fibrosis.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PELTZ, GARY A — STANFORD UNIVERSITY
- Study coordinator: PELTZ, GARY A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.