Condition

Metabolic Dysfunction-Associated Steatotic Liver Disease clinical trials and research

• 24Clinical trials
• 2New in 30 days
• 37Countries

Newest Metabolic Dysfunction-Associated Steatotic Liver Disease clinical trials

All recruiting trials (24)

• Health profile of MASLD in Kazakhstan and real-world use of Ursosan in Almaty

  This study tests how MASLD appears in adults in Kazakhstan and how Ursosan is used in real-world care for a subgroup in Almaty.

  Recruiting at 7 sites Kazakh Association of Internal Medicine Specialists · Aktobe, Aktobe and 6 other locations · NCT07889999

• Endohepatology-based reclassification of treatment indication in high-risk MASLD

  This study tests whether an endohepatology assessment can change treatment decisions for adults with high-risk MASLD.

  Recruiting University Hospital Muenster · Münster · NCT07877272

• ALN-CIDEB in adults with MASLD to see if it helps the liver

  This study tests whether ALN-CIDEB can help adults with MASLD and its liver damage compared to placebo.

  Recruiting at 4 sites Phase 3 Regeneron Pharmaceuticals · Miami, Florida and 3 other locations · NCT07854782

• Liver Fat and Scarring in People Suspected of Non-Celiac Wheat Sensitivity

  This study looks to see if people with non-celiac wheat sensitivity have liver fat or fibrosis and how this relates to IBS/FD and celiac disease.

  Recruiting at 2 sites University of Palermo · Palermo, Palermo and 1 other locations · NCT07750535

• Taiwan green propolis for MASLD and lipid/metabolic issues

  This study tests whether Taiwan green propolis capsules can improve blood lipids and body fat in adults with MASLD compared to a placebo over 12 weeks.

  Recruiting Taipei Medical University · Dalin · NCT07692438

• Secukinumab retention in adults with plaque psoriasis and MASLD in Spain

  This study tests how long people with plaque psoriasis and MASLD stay on secukinumab in real-world Spain, using EMR data from several hospitals.

  Recruiting at 9 sites Novartis · Badalona, Barcelona and 8 other locations · NCT07683065

• Automated Passive Case-Finding for Advanced Liver Fibrosis in MASLD

  This program automatically screens high‑risk adults aged 50–75 in primary care to see if they have advanced liver fibrosis and possible MASLD, using routine blood tests and reflex lab tests without extra work for clinicians.

  Recruiting Hospital General Universitario Gregorio Marañon · Madrid, Madrid · NCT07658755

• Smart Diets for MASLD in teens

  This phase 2 trial tests whether essential amino acids and/or a low-sugar diet can help teens with MASLD, high BMI, and liver fat see improvements.

  Recruiting Phase 2 Michigan State University · Grand Rapids, Michigan · NCT07459504

• Hong Kong registry for diabetes-related fatty liver disease

  This project will see how common and how severe fatty liver is among adults with type 2 diabetes in Hong Kong.

  Recruiting Chinese University of Hong Kong · Hong Kong, New Territories · NCT07437157

• Rifaximin-α treatment for metabolic dysfunction‑associated steatotic liver disease

  This trial will test whether taking Rifaximin‑α daily for 24 weeks can reduce liver fat and improve metabolic markers in adults with MASLD.

  Recruiting Early Phase 1 Shanghai Changzheng Hospital · Shanghai · NCT07381257

• Testing retatrutide and tirzepatide to prevent serious liver complications in adults with high‑risk MASLD

  This trial tests whether retatrutide or tirzepatide can prevent major liver complications in adults with high‑risk metabolic dysfunction‑associated steatotic liver disease identified by noninvasive tests.

  Recruiting at 502 sites Phase 3 Eli Lilly and Company · Tuscaloosa, Alabama and 562 other locations · NCT07165028

• Finding advanced liver fibrosis in MASLD patients during primary care visits

  This project will test an electronic health record alert that helps primary care teams identify MASLD patients at higher risk of advanced liver fibrosis so they can be referred for confirmatory testing.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07159386

• Low‑methoxy pectin for inflammation, gut microbiome, and metabolic health in MASLD

  This tests whether taking daily low‑methoxy pectin for six weeks can reduce inflammation and improve gut bacteria and metabolic markers in adults with MASLD.

  Recruiting at 3 sites University of Nottingham · Nottingham, United Kingdom and 2 other locations · NCT07093346

• Targeting liver fat with the CMNT intermittent diet for people with type 2 diabetes and fatty liver

  This study will try a CMNT intermittent energy‑restriction diet to see if lowering liver fat helps adults with type 2 diabetes and nonalcoholic fatty liver disease.

  Recruiting at 3 sites State Key Laboratory of Subhealth Intervention Technology · Yichang, Hubei and 2 other locations · NCT07083336

• Link between biological aging and type 2 diabetes risk in people with liver disease

  This study looks at how biological aging might affect the risk of developing type 2 diabetes in people with liver disease and those without it.

  Recruiting Ningbo No. 1 Hospital · Ningbo, Zhejiang · NCT06984510

• Aspirin treatment for liver disease related to metabolic dysfunction

  This study is testing if taking low-dose aspirin every day can help people with liver disease caused by metabolic issues feel better and slow down the disease.

  Recruiting Phase 2 Taichung Veterans General Hospital · Taichung, Taiwan · NCT06935994

• Investigating a probiotic treatment for fatty liver disease

  This study is testing whether a specific probiotic can help people with fatty liver disease improve their health compared to a placebo.

  Recruiting National Taiwan University Hospital · Taipei · NCT06873165

• Link between MASH and mitochondrial membrane changes in people having bariatric surgery.

  We will test whether changes in mitochondria-associated membranes (MAMs) in liver cells and blood immune cells are linked to MASH in adults undergoing bariatric surgery.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 1 other locations · NCT06868992

• Evaluating metabolic features in patients with liver disease

  This study is trying to see how different metabolic factors affect liver health in people with a specific liver disease called MASLD in Egypt.

  Recruiting Tanta University · Tanta, Gharbyea · NCT06867419

• Identifying Prognostic Factors for Liver Disease and Transplant Needs

  This study is trying to find out which factors can help predict if people with certain liver diseases will need a transplant or develop liver cancer.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06813508

• Indian-style Mediterranean diet versus low-fat diet to reduce liver fat in overweight children with MASLD

  This project will try to see if an Indianized Mediterranean diet or a low-fat diet better reduces liver fat in overweight children and teens with MASLD over 180 days.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT06768216

• Hormone therapy's effect on liver disease in postmenopausal women

  This study is testing if hormone replacement therapy can help postmenopausal women with liver disease by looking at how it affects liver fat and overall health.

  Recruiting Phase 1 University of Oxford · Oxford, Oxfordshire · NCT06704516

• Targeting Skeletal Muscle to Help MASLD

  We are testing whether different levels of exercise can lower muscle fat content and improve MASLD in adults who have excess muscle fat.

  Recruiting at 2 sites Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels and 1 other locations · NCT06506513

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

Related topics

Quick answers

How many Metabolic Dysfunction-Associated Steatotic Liver Disease clinical trials are recruiting right now?

24, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in Taiwan (4 trials), China (4 trials), United States (4 trials), Italy (3 trials), Spain (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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