Condition

HPV Infection clinical trials and research

• 28Clinical trials
• 18NIH research projects
• 24Countries

Newest HPV Infection clinical trials

All recruiting trials (28)

• Risk of cervical cancer after HPV detection in healthy women

  This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

  Recruiting Karolinska Institutet · Stockholm · NCT07850128

• Dysplasix™ intravaginal suppositories for women with high‑risk HPV and mild cervical cell changes

  This trial tests whether nightly Dysplasix™ vaginal suppositories can clear high‑risk HPV and help mild cervical cell changes (ASC‑US or LSIL) in adult women.

  Recruiting Phase 2 Amplexd Therapeutics, Inc. · Shatin, New Territories · NCT07572396

• At-home HPV self-collection kits for cervical cancer screening

  We are testing different ways to give at-home HPV self-collection kits to under-screened people aged 25–65 to see if more of them complete cervical cancer screening and follow-up.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07453459

• Comparing clinic-only versus clinic plus community outreach to offer HPV self-collection for cervical screening in women with HIV

  This project will test whether adding community health worker outreach to clinic services helps more women living with HIV complete HPV self-collection for cervical screening.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Kampala · NCT07428330

• CHW4CervixHealth: HPV self-collection kits with community health workers

  This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07336134

• Q-Pad menstrual-pad test to detect high-risk HPV and cervical precancer

  This study tests whether a home menstrual-pad kit (Q-Pad) can detect high-risk HPV and cervical precancer in people referred for colposcopy after an abnormal Pap or HPV result.

  Recruiting at 3 sites Qurasense · New Haven, Connecticut and 2 other locations · NCT07281599

• Same-day HPV screen-and-treat for women with HIV in La Romana

  This project will test whether offering same-day HPV screening and immediate treatment improves detection and treatment completion for Spanish-speaking women living with HIV in La Romana, Dominican Republic.

  Recruiting Columbia University · La Romana · NCT07225530

• Mail-delivered mouth rinse and saliva kits for HPV testing in people with HIV

  This project tests whether people living with HIV can collect mouth rinse and saliva samples at home, mail them in, and get HPV test results that match clinic-collected samples.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07087145

• 15-valent HPV vaccine for people aged 9–45 in China.

  This trial will test whether a 15‑valent HPV vaccine is safe and prompts immune responses in people aged 9–45.

  Recruiting Phase 2 Shanghai Bovax Biotechnology Co., Ltd. · Nanning, Guangxi · NCT06756269

• Assessing screening methods for anal intraepithelial neoplasia in HPV patients

  This study is testing different screening methods to see which one best finds anal cell changes in people who have survived HPV-related cancers.

  Recruiting PCK Marine Hospital in Gdynia · Gdynia, Pomeranian Voivodeship · NCT06574087

• HPV molecular patterns linked to high-grade anal lesions and cancer in former IPERGAY participants

  This project will test whether specific HPV molecular signatures predict high-grade anal lesions or anal cancer in people who were part of the IPERGAY HPV substudy about 10 years earlier.

  Recruiting at 3 sites ANRS, Emerging Infectious Diseases · Lyon and 2 other locations · NCT06522256

• Self-collected versus clinician-collected anal swabs for HPV screening in people living with HIV in Réunion

  This study tries to see if people living with HIV aged 30 and older can collect their own anal swab as accurately and comfortably as a healthcare professional for HPV screening.

  Recruiting Centre Hospitalier Universitaire de la Réunion · Saint-Denis and 1 other locations · NCT06507917

• Using a portable colposcope for cervical cancer screening

  This study is testing a portable device to help screen women for cervical cancer and HPV in Kenya, aiming to improve diagnosis and treatment options.

  Recruiting Duke University · Nairobi · NCT06458062

• Comparing two treatments for cervical cancer risk reduction in women living with HIV in Mozambique

  This study is testing two different treatments for pre-cancerous cervical lesions in women living with HIV in Mozambique to see which one works better in getting rid of high-risk HPV.

  Recruiting Instituto Nacional de Saúde, Mozambique · Maputo · NCT06326294

• Non-invasive plasma treatment for HPV infections

  This study is testing a new non-invasive plasma treatment to see if it can help people clear HPV infections without causing any cervical issues.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06291311

• Using a dietary supplement to prevent HPV infection persistence

  This study tests if a dietary supplement with EGCG, folic acid, and vitamin B12 can help people with cervical HPV infections avoid long-term problems that could lead to cancer.

  Recruiting Lo.Li.Pharma s.r.l · Modena, Modena · NCT06285357

• pBI-11 DNA vaccine delivered by electroporation for HPV16/18 cervical infection

  This study tests whether the pBI-11 DNA vaccine given with an electroporation device is safe and feasible and may help clear HPV16/18 in women with persistent cervical infection.

  Recruiting Phase 2 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Birmingham, Alabama and 1 other locations · NCT06210854

• Estimating the prevalence of high-risk HPV infections in women and girls across multiple countries

  This study is trying to find out how common high-risk HPV infections are in girls and women aged 9-50 in different countries, especially in low-income areas.

  Recruiting International Vaccine Institute · Dhaka and 7 other locations · NCT06129253

• Topical treatment for high-grade vulvar lesions

  This study is testing a new ointment to see if it can help women with high-grade vulvar lesions caused by HPV without needing surgery.

  Recruiting at 5 sites Phase 2 Frantz Viral Therapeutics, LLC · Fort Myers, Florida and 4 other locations · NCT06075264

• Comparing two treatments for persistent low-grade cervical lesions caused by high-risk HPV

  This study is testing whether a new light therapy or a laser treatment is better at helping women with long-lasting low-grade cervical lesions caused by high-risk HPV.

  Recruiting First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06052033

• Understanding HPV Infection in Men with Inflammatory Bowel Disease

  This study looks at how common HPV infections are in men with Inflammatory Bowel Disease by testing samples from their mouths and bottoms to see if there are any related health risks.

  Recruiting Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona · NCT05911750

• Testing a new treatment for HPV16-infected women

  This study is testing a new treatment for women aged 18-49 who are infected with HPV16 to see if it can help their immune system fight the virus and improve cervical health.

  Recruiting Phase 1 BlueSky Immunotherapies GmbH · Bratislava · NCT05829629

• Improving HPV vaccination rates through enhanced physician communication

  This study is testing a new online way for doctors to talk to teens about getting the HPV vaccine to see if it helps more of them get vaccinated compared to the usual method.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT05336240

• Investigating HPV and skin cancer risks in organ transplant recipients

  This study is trying to see if organ transplant recipients have a higher risk of HPV infections and skin cancer compared to people with normal immune systems.

  Recruiting at 3 sites Bispebjerg Hospital · Copenhagen NV, Capital Region and 2 other locations · NCT05284877

• Male HPV vaccination added to girls’ program in Tanzania

  This trial tests whether adding a single-dose HPV vaccine for boys ages 14–18 to the existing girls’ vaccination program changes HPV infection rates in young adults in northern Tanzania.

  Recruiting Phase 4 London School of Hygiene and Tropical Medicine · Mwanza · NCT04953130

• HPV vaccination and screening for cervical cancer in young women in Sweden

  This study is testing whether giving the HPV vaccine and screening for cervical cancer at the same time can help young women in Sweden reduce HPV infections more quickly.

  Recruiting Phase 4 Region Stockholm · Stockholm · NCT04910802

• Using Artesunate Vaginal Inserts to Treat Cervical Pre-Cancer

  This study is testing whether artesunate vaginal inserts can help women with cervical pre-cancer feel better and improve their condition.

  Recruiting at 7 sites Phase 2 Frantz Viral Therapeutics, LLC · Fort Myers, Florida and 6 other locations · NCT04098744

• Monitoring high-grade cervical lesions without immediate surgery

  This study is testing if young women with certain cervical lesions can safely avoid surgery by just being monitored over two years to see if their condition improves on its own.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT04057924

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria

  This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.

  NIH research Northwestern University · Chicago, United States · NIH-11401243

• Antibodies and vaginal bacteria in HPV-related cervical changes

  This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11398821

• Oral bacteria, gum disease, and oral HPV in people living with HIV

  This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.

  NIH research Emory University · Atlanta, United States · NIH-11384763

• How HIV Treatment Might Change Oral HPV Risk

  A study explored how antiretroviral therapy for HIV could affect the mouth’s lining and the chance of catching oral HPV, with participants including people living with HIV on ART and people using ART for PrEP.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11352535

• Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients

  This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11302466

• Understanding how HIV medication affects oral HPV infection

  This research explores if medications for HIV or HIV prevention might make people more likely to get oral human papillomavirus (HPV) infections.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11193516

• Oral HPV-related mouth and throat cancer risk in people with HIV in Nigeria

  This project looks for DNA changes in mouth samples that could help spot and predict HPV-related mouth and throat cancers in people living with HIV in Nigeria.

  NIH research Northwestern University · Chicago, United States · NIH-11167776

• Antibodies and vaginal bacteria in HPV and cervical cell changes

  This research looks at how antibodies attach to vaginal bacteria in people with HPV or different levels of cervical cell changes to better understand why some infections clear and others progress.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11164509

• Mouth bacteria, gum disease, and oral HPV in people living with HIV

  This project looks at whether mouth bacteria and gum disease are linked to getting or keeping oral HPV in people living with HIV.

  NIH research Emory University · Atlanta, United States · NIH-11158633

• Developing New Medicines to Fight HPV Infection

  This research looks for new medicines that can stop the human papillomavirus (HPV) from causing cancer.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11078681

• Understanding how HPV infection affects oral cancer in HIV-positive individuals in Nigeria

  This study is looking at how HPV infections might affect the risk of oral cancers in people living with HIV in Nigeria, and it hopes to find ways to help prevent and catch these cancers early by understanding changes in gene activity.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10913421

• The connection between oral bacteria, gum disease, and HPV infection in people with HIV

  This study is looking at how the bacteria in your mouth and gum diseases might affect HPV infections in people living with HIV, and it wants to learn how social factors play a role in this, so we can better understand why HPV-related cancers are more common in this group.

  NIH research Emory University · Atlanta, United States · NIH-10894827

• Investigating how antiretroviral therapy affects the risk of oral HPV infection in people with HIV

  This study is looking at how taking HIV medication might affect the risk of getting oral HPV in people living with HIV, and it will compare those on treatment to others who are HIV-negative, to help understand how these medications impact oral health.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-10893234

• Testing urine samples for HPV and cervical cancer screening in women with HIV in Malawi and South Africa

  This study is looking at whether testing urine samples can help check for HPV and cervical cancer in women living with HIV in Malawi and South Africa, making it easier and more affordable for them to get screened.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-10891543

• Understanding how HIV affects oral cells and their risk for HPV infection

  This study is looking at how the mouth cells of people living with HIV might not work as well, which could make them more likely to get HPV, and it aims to find out how these cells differ from those of healthy people.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10880690

• Investigating how bacteria and antibodies interact during HPV infection and cervical dysplasia

  This study is looking at how certain bacteria in the vagina might affect the immune system and the risk of cervical issues in women with high-risk HPV infections, helping us understand how these factors could influence HPV clearance and the chances of developing cervical cancer.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10867912

• Understanding how a protein complex helps HPV infect cells

  This study is looking at how a protein called gamma-secretase helps the human papillomavirus (HPV) get into our cells, which is important because HPV can lead to certain cancers, and the researchers want to understand this process better to find ways to stop it.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10768764

• Understanding how oral HPV infection affects cancer risk in people living with HIV

  This study is looking at why people with HIV, especially those in Hispanic communities, have higher rates of oral HPV infections and throat cancers, and it aims to find ways to help prevent these issues.

  NIH research Comprehensive Cancer Center/ Univ/pr · San Juan, United States · NIH-10677502

Related topics

Quick answers

How many HPV Infection clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (8 trials), France (2 trials), China (2 trials), Sweden (2 trials), Tanzania (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 4: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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