At-home HPV self-collection kits for cervical cancer screening
Official title: Feasibility of Community-based Distribution of HPV Self-Collection Kits for At Home Cervical Cancer Screening
Run by Washington University School of Medicine · NCT07453459 · Data updated 2026-11-12
We are testing different ways to give at-home HPV self-collection kits to under-screened people aged 25–65 to see if more of them complete cervical cancer screening and follow-up.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years and up |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Washington University School of Medicine Academic / other |
| Locations | 1 site (St Louis, Missouri) |
| Status | Recruiting |
| Started | April 17, 2026 |
| Main results expected | November 15, 2027 |
| Study ends | January 15, 2028 |
| Registry record updated | July 27, 2026 |
| Trial ID | NCT07453459 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People aged 25–65 with an intact cervix who report no cervical cancer screening in the past 3 years, have a smartphone and internet access, and can read and speak English are ideal candidates.
✕Probably not a fit
Those who are currently pregnant or recently postpartum, have abnormal vaginal bleeding, a history of reproductive system cancer, a compromised immune system, prior DES exposure, recent treatment for cervical precancer, are already up-to-date on screening, or lack a smartphone/internet access are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This equity-focused, community-based project compares the feasibility of different distribution methods for at-home HPV self-collection kits among under-screened individuals with a cervix. Participants use a smartphone and the Teal Health app and join virtual visits; some arms add in-person registration and navigation. The study collects qualitative interviews and measures kit return and adherence to follow-up after abnormal results. Activities are centered through Washington University School of Medicine with virtual and some in-person components.
Why it matters
Potential benefit: If successful, this approach could increase screening uptake and timely follow-up, helping detect precancers earlier in under-screened populations.
How similar studies have gone: Previous research has shown that mailed or home HPV self-sampling can increase screening uptake in under-screened groups, so this approach builds on promising evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Are age 25 or older * Has an intact cervix * Self-reports that they have not been screened for cervical cancer within the last 3 years for 25-64, 5 years for 65 or older * Has a cellphone that can receive texts (including verification codes) and an email account * Has access to the internet to engage with the Teal Health mobile app and complete a Zoom interview * Can read, speak, write and understand English well enough to take a survey and complete an interview Exclusion Criteria: * Abnormal vaginal bleeding or discharge * A history of cancer of the reproductive system * A compromised immune system * Prior Diethylstilbestrol (DES) exposure * Currently pregnant or are within 6 weeks of giving birth * Treatment for a cervical precancer (e.g., loop electrosurgical excision procedure or conization) in the last 25 years.
Where it's running
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Washington University School of Medicine
St Louis, Missouri, United States Recruiting
Study contacts
- Principal investigator: Michelle Silver, PhD, ScM — Washington University School of Medicine
- Study coordinator: Michelle Silver, PhD, ScM
- Email: michelle.silver@wustl.edu
- Phone: 314-454-7903
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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CHW4CervixHealth: HPV self-collection kits with community health workers
This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.
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Same-day HPV screen-and-treat for women with HIV in La Romana
This project will test whether offering same-day HPV screening and immediate treatment improves detection and treatment completion for Spanish-speaking women living with HIV in La Romana, Dominican Republic.
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Using a portable colposcope for cervical cancer screening
This study is testing a portable device to help screen women for cervical cancer and HPV in Kenya, aiming to improve diagnosis and treatment options.
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Non-invasive plasma treatment for HPV infections
This study is testing a new non-invasive plasma treatment to see if it can help people clear HPV infections without causing any cervical issues.
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Investigating HPV and skin cancer risks in organ transplant recipients
This study is trying to see if organ transplant recipients have a higher risk of HPV infections and skin cancer compared to people with normal immune systems.
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HPV vaccination and screening for cervical cancer in young women in Sweden
This study is testing whether giving the HPV vaccine and screening for cervical cancer at the same time can help young women in Sweden reduce HPV infections more quickly.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.