Comparing two treatments for cervical cancer risk reduction in women living with HIV in Mozambique

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of thermal ablation (TA) and loop electrosurgical excision procedure (LEEP) in treating pre-cancerous cervical lesions and HPV infections in women living with HIV (WLWH) in Mozambique. It will assess the effectiveness of both treatments in eradicating high-risk HPV and managing biopsy-confirmed CIN 2/3. Additionally, the study will identify factors that contribute to treatment failure and develop a predictive tool to help tailor alternative treatments for patients at risk of failure. The findings will provide local evidence to inform health policy and improve adherence to cervical cancer prevention strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ages 25-49 years;
* confirmed HIV infection;
* physically and mentally willing and able to participate in the study, and provide informed consent.

Exclusion Criteria:

* currently pregnant or \<6 weeks post-partum;
* had a hysterectomy and no longer have a cervix;
* a history of cervical cancer or treatment for cervical abnormalities; and
* any medical, psychiatric, or other condition that would interfere with protocol adherence, assessment of safety, and/or ability/competence to provide informed consent.

Where it's running

• INSMozambique
  Maputo, Mozambique Recruiting

Study contacts

• Principal investigator: Edna Viegas, MD, PhD — Instituto Nacional de Saúde, Mozambique
• Study coordinator: Edna Viegas, MD, PhD
• Email: edna.viegas@ins.gov.mz
• Phone: +258823060500

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using Artesunate Vaginal Inserts to Treat Cervical Pre-Cancer

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.