Condition

HPV clinical trials and research

• 34Clinical trials
• 16Countries

Newest HPV clinical trials

All recruiting trials (34)

• Can people collect their own vaginal sample for HPV testing as well as clinician collection for comparison?

  This study tests whether individuals can correctly use a self-collection device to gather a vaginal sample for high-risk HPV screening and whether the self-collected sample agrees with clinician-collected samples.

  Recruiting at 11 sites Mel Mont Medical · Phoenix, Arizona and 10 other locations · NCT07758140

• Two-probe thermal ablation for cervical precancer in WLWH in South Africa

  This study tests whether using two probes for thermal ablation is safer or more effective than one probe for treating cervical precancer in women living with HIV in South Africa.

  Recruiting Fred Hutchinson Cancer Center · Durban · NCT07645378

• Two-probe thermal ablation for cervical precancer in WLWH in Zimbabwe

  This study tests whether using two TA probes (endocervical and ectocervical) is better than one probe for treating cervical precancer in women living with HIV in Zimbabwe.

  Recruiting Fred Hutchinson Cancer Center · Harare · NCT07645352

• Digital tools to boost HPV vaccination intentions among Nigerian caregivers

  This study tests whether different online content can help Nigerian parents of unvaccinated girls ages 9-14 decide to vaccinate their daughters against HPV.

  Recruiting University of Pennsylvania · Lagos · NCT07498075

• HPV monitoring after chemoradiotherapy for cervical cancer

  This project will test whether HPV detected on cervical swabs and in blood can find cancer recurrence in people with stage IB–IVA cervical cancer after curative chemoradiotherapy.

  Recruiting General University Hospital, Prague · Prague · NCT07493928

• Two-probe thermal ablation for cervical precancer in HIV+ women in Kenya

  This study tests whether using two probes for thermal ablation is more effective and acceptable than one probe for treating cervical precancer in women living with HIV in Kenya.

  Recruiting Fred Hutchinson Cancer Center · Nairobi · NCT07468695

• Self-swab versus clinician-collected HPV screening for vulnerable women in Reunion

  This study tests whether self-collected swabs work as well and feel as acceptable as clinician-collected swabs for HPV screening in vulnerable women aged 30–65.

  Recruiting at 2 sites Centre Hospitalier Universitaire de la Réunion · Saint-Paul and 1 other locations · NCT07438080

• Two-probe thermal ablation for cervical precancer in WLWH in Rwanda

  This study tests whether using two probes for thermal ablation is safer or more effective than one probe for treating cervical precancer in women living with HIV in Rwanda.

  Recruiting Fred Hutchinson Cancer Center · Kigali · NCT07390916

• Self-sampling HPV screening offered in the emergency department

  This project tests whether offering HPV self-sampling in the emergency department helps more people aged 30–65 with a cervix get screened for cervical cancer.

  Recruiting University of Rochester · Rochester, New York · NCT07345897

• CHW4CervixHealth: HPV self-collection kits with community health workers

  This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07336134

• Q-Pad menstrual-pad test to detect high-risk HPV and cervical precancer

  This study tests whether a home menstrual-pad kit (Q-Pad) can detect high-risk HPV and cervical precancer in people referred for colposcopy after an abnormal Pap or HPV result.

  Recruiting at 3 sites Qurasense · New Haven, Connecticut and 2 other locations · NCT07281599

• How menstrual cups, tampons, and pads affect vaginal microbiota and immunity

  This project will see if using menstrual cups, tampons, or pads is linked to changes in vaginal bacteria, local immune responses, or recurrence of common vaginal infections in adult women.

  Recruiting Centre National de la Recherche Scientifique, France · Paris, Île-de-France Region · NCT07199998

• Adaptive pre-surgery treatment for untreated HPV‑negative locoregional head and neck cancer

  This trial will test whether giving volrustomig with paclitaxel and carboplatin before standard therapy can shrink tumors in adults with untreated, locally advanced HPV‑negative head and neck squamous cell carcinoma.

  Recruiting Phase 2 University of Chicago · Chicago, Illinois · NCT07065630

• Anal cancer screening for men on PrEP

  This study will test how well anal swabs and DNA methylation testing find high-grade anal lesions (HSIL) and how common those lesions are in men who have sex with men using PrEP, and whether HSIL affects quality of life.

  Recruiting at 6 sites Universitair Ziekenhuis Brussel · Bruges and 7 other locations · NCT07029152

• Papillex® for abnormal cervical cells caused by HPV

  This trial will see if taking Papillex® for 180 days helps abnormal cervical cells caused by HPV improve in women aged 25–55 with CIN 1 or 2.

  Recruiting Papillex Inc. · London, Ontario · NCT06979180

• Reducing treatment intensity for HPV-positive oropharyngeal cancer

  This study is testing if lowering radiation doses and skipping chemotherapy can still help patients with HPV-positive throat cancer live longer and feel better while reducing side effects.

  Recruiting at 2 sites Georgetown University · Washington D.C., District of Columbia and 1 other locations · NCT06902623

• Investigating multiple HPV infections and their role in cervical changes

  This study looks at how common multiple high-risk HPV infections are in people with abnormal cervical tests to see how they might affect cervical health.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT06862102

• One-dose HPV vaccine versus two- and three-dose schedules

  This study will see if one dose of the HPV vaccine gives the same immune response as two or three doses in healthy adults aged 18 to 45.

  Recruiting Phase 4 Emory University · Decatur, Georgia · NCT06799494

• HPV self-collection program for cervical cancer screening

  This study tests a new program that lets women overdue for cervical cancer screening collect their own samples at home or in the clinic to see if it helps them get screened more easily and follow up on any positive HPV results.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06674681

• Improving HPV vaccination rates through standing orders

  This study tests if allowing healthcare team members to give HPV vaccines without needing a doctor's order can help more kids aged 11-12 get vaccinated.

  Recruiting University of Rochester · Rochester, New York · NCT06380114

• Assessing regression of cervical precancerous lesions and risk factors

  This study is testing how well certain treatments help women with severe cervical precancerous lesions get better and if there are specific factors that can predict their recovery.

  Recruiting General University Hospital, Prague · Prague · NCT06147388

• Community-based strategy to improve cervical cancer screening access

  This study is testing a new way for women in low-resource communities in Texas to get cervical cancer screenings using self-sample HPV testing with help from community health workers.

  Recruiting at 2 sites M.D. Anderson Cancer Center · Austin, Texas and 1 other locations · NCT06109870

• Adjuvant Gardasil 9 Vaccination for Women Treated for Vulvar HSIL

  This study tests whether giving Gardasil 9 after treatment for vulvar HSIL can help prevent recurrence in women 18 and older.

  Recruiting Phase 4 Erasmus Medical Center · Rotterdam · NCT06052696

• Study of gut and vaginal microbiota in women living with HIV

  This study looks at how the balance of bacteria in the vagina affects the risk of HPV infection and cervical issues in women living with HIV in China.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05996016

• Using games to encourage vaccinations in children

  This study tests if using fun games can help kids aged 11-14 feel more confident about getting their HPV and COVID-19 vaccines.

  Recruiting Michigan State University · Chandler, Arizona · NCT05984849

• Treatment approaches for HPV-related lesions in women

  This study looks at whether getting vaccinated after surgery for HPV-related lesions can help reduce the chances of women developing cervical dysplasia or cancer later on.

  Recruiting Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan, Lombardy · NCT05938192

• mSaada mobile app to support HPV-based cervical screening and follow-up

  This project will test whether the mSaada mobile app helps community health volunteers in Kenya increase HPV screening and ensure women aged 30–65 get follow-up and treatment.

  Recruiting Duke University · Kisumu, Kisumu County · NCT05848557

• Reduced dosing of the HPV vaccine for women living with HIV

  This study is testing if a lower dose of the HPV vaccine can effectively protect women living with HIV from HPV and cervical cancer.

  Recruiting at 5 sites Phase 4 University of British Columbia · Surrey, British Columbia and 9 other locations · NCT05495906

• Lower radiation therapy combined with standard chemotherapy for HPV-positive throat cancer

  This study is testing whether using less radiation therapy along with standard chemotherapy can help people with HPV-positive throat cancer feel better while causing fewer side effects.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05491512

• Using blood tests to determine treatment timing for HPV-related throat cancer

  This study is testing if blood tests can help decide when to start treatment for people with HPV-related throat cancer after surgery, by checking their tumor DNA levels.

  Recruiting at 8 sites Phase 2 Memorial Sloan Kettering Cancer Center · Miami, Florida and 7 other locations · NCT05307939

• New HPV vaccine tested in healthy volunteers

  This study is testing a new HPV vaccine in healthy adults aged 18-45 to see if it can safely boost their immune response against different types of HPV that can cause cancer.

  Recruiting Early Phase 1 German Cancer Research Center · Heidelberg · NCT05208710

• Automated cervical cancer screening using a smartphone AI classifier

  This study is testing a smartphone app that uses AI to help improve cervical cancer screening in low- and middle-income countries by making it more accurate and easier for healthcare providers.

  Recruiting University Hospital, Geneva · Dschang, Menoua · NCT04859530

• Surgical removal of eye-surface squamous tumors in people living with HIV in Sub-Saharan Africa

  We will try surgical removal of suspected eye-surface squamous tumors in people living with HIV in sub‑Saharan Africa and follow them for 12 months to see how surgery, tissue testing, and follow-up care work.

  Recruiting AIDS Malignancy Consortium · Kampala · NCT04704648

• Understanding severe viral infections in patients without known immune issues

  This study is trying to understand why some healthy people get severe viral infections and how different tests can help figure it out.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01011712

Related topics

Quick answers

How many HPV clinical trials are recruiting right now?

34, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (14 trials), Czechia (2 trials), Kenya (2 trials), Canada (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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