How HIV Treatment Might Change Oral HPV Risk
Official title: The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
Funded at Lsu Health Sciences Center · NIH-11352535 · Data updated 2026-11-12
A study explored how antiretroviral therapy for HIV could affect the mouth’s lining and the chance of catching oral HPV, with participants including people living with HIV on ART and people using ART for PrEP.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 16, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $630,689 |
| NIH project number | 5R01DE033878-03 |
| Project ID | NIH-11352535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV on ART, individuals using ART for PrEP, and HIV-negative controls who can provide oral tissue samples.
✕Less likely to help
Healthy individuals not using ART or not at risk for HIV-related HPV infection may not benefit.
What this research studies
This project asks whether ART affects the health of the oral mucosa and makes HPV infection more likely. Researchers plan to compare oral HPV prevalence between people living with HIV on ART, people taking ART for PrEP, and HIV-negative controls. They will examine tissue structure in the mouth and assess how ART exposure relates to HPV risk in real-life clinical samples. The work uses 3D tissue models and patient samples to translate lab findings into patient-relevant insights.
Why it matters
Potential benefit: If successful, findings could inform safer ART use and HPV prevention strategies for people with and without HIV.
How similar studies have gone: Previous 3D tissue studies suggested ART may alter mucosal structure, but clinical confirmation is needed; this study builds on that by using patient samples.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Cameron, Jennifer Erin — Lsu Health Sciences Center
- Study coordinator: Cameron, Jennifer Erin
Related research
Other NIH-funded projects on the same topics.
-
Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria
This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.
-
Antibodies and vaginal bacteria in HPV-related cervical changes
This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.
-
Oral bacteria, gum disease, and oral HPV in people living with HIV
This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.
-
Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients
This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.
-
Understanding how HIV medication affects oral HPV infection
This research explores if medications for HIV or HIV prevention might make people more likely to get oral human papillomavirus (HPV) infections.
-
Oral HPV-related mouth and throat cancer risk in people with HIV in Nigeria
This project looks for DNA changes in mouth samples that could help spot and predict HPV-related mouth and throat cancers in people living with HIV in Nigeria.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.