Understanding how HPV infection affects oral cancer in HIV-positive individuals in Nigeria
Official title: Epigenetic study of oral HPV infection-associated oral cancer in people living with HIV in Nigeria
Funded at Northwestern University at Chicago · NIH-10913421 · Data updated 2026-11-12
This study is looking at how HPV infections might affect the risk of oral cancers in people living with HIV in Nigeria, and it hopes to find ways to help prevent and catch these cancers early by understanding changes in gene activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 16, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $779,097 |
| NIH project number | 5R01CA274952-03 |
| Project ID | NIH-10913421 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are at risk for HPV infections and oral cancers.
✕Less likely to help
Patients who do not have HIV or those without HPV infections may not benefit from this research.
What this research studies
This research investigates the link between Human papillomavirus (HPV) infections and oral cancers in people living with HIV in Nigeria. It aims to identify how epigenetic changes, which are modifications in gene expression, can indicate the risk of developing these cancers. By studying the prevalence of HPV and its interaction with HIV, the research seeks to develop targeted interventions for better prevention and early detection of oral and oropharyngeal cancers. Patients may be involved in providing samples and data to help understand these relationships.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and early detection methods for oral cancers in HIV-positive individuals.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between HPV and cancer in similar populations, indicating that this approach has potential for success.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Hou, Lifang — Northwestern University at Chicago
- Study coordinator: Hou, Lifang
Related research
Other NIH-funded projects on the same topics.
-
Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria
This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.
-
Oral HPV-related mouth and throat cancer risk in people with HIV in Nigeria
This project looks for DNA changes in mouth samples that could help spot and predict HPV-related mouth and throat cancers in people living with HIV in Nigeria.
-
Mobile platform using AI to screen for oral cancer in low-resource communities
A low-cost, AI-powered mobile tool helps frontline healthcare workers screen for oral cancer and triage patients in communities with limited access to specialists.
-
Endosomal signaling and cancer pain control in oral cancer
A study to understand how signals inside nerve cells and supportive cells contribute to pain in people with oral cancer.
-
Affordable AI-enabled point-of-care tool for quick oral cancer checks
A low-cost AI-powered imaging module helps clinicians screen for oral cancer at the point of care, especially in community and resource-limited settings.
-
How tissue stiffness affects oral cancer spread
A researcher at UC San Diego is studying how the stiffness of mouth tissue influences the behavior of oral cancer cells in people.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.