Testing urine samples for HPV and cervical cancer screening in women with HIV in Malawi and South Africa
Official title: Project 1: Urine sampling for HPV infection and methylation testing for cervical cancer screening among women living with HIV in Malawi and South Africa
Funded at Univ of North Carolina Chapel Hill · NIH-10891543 · Data updated 2026-11-12
This study is looking at whether testing urine samples can help check for HPV and cervical cancer in women living with HIV in Malawi and South Africa, making it easier and more affordable for them to get screened.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 13, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $228,075 |
| NIH project number | 5U54CA254564-05 |
| Project ID | NIH-10891543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women living with HIV in Malawi and South Africa who are at risk for cervical cancer.
✕Less likely to help
Patients who are not living with HIV or those who do not reside in Malawi or South Africa may not benefit from this research.
What this research studies
This research investigates the effectiveness of using urine samples to test for HPV infection and methylation as a method for cervical cancer screening among women living with HIV in Malawi and South Africa. The study aims to provide a cost-effective and scalable screening approach, particularly in clinical settings where traditional pelvic examinations are not feasible. By validating urine-based HPV testing, the research seeks to improve cervical cancer screening coverage for HIV-positive women, who are at a higher risk for cervical cancer. The project will be conducted at established cervical screening clinics in the two countries.
Why it matters
Potential benefit: If successful, this research could significantly enhance cervical cancer screening accessibility and early detection for women living with HIV.
How similar studies have gone: Previous research has shown promise in using alternative sampling methods for HPV testing, indicating potential success for this approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Chibwesha, Carla J — Univ of North Carolina Chapel Hill
- Study coordinator: Chibwesha, Carla J
Related research
Other NIH-funded projects on the same topics.
-
mSaada: a mobile tool to boost cervical cancer screening in western Kenya
A mobile app helps community health volunteers manage cervical cancer screening tasks and follow-up for women in low-resource areas.
-
HPV self-collection in HIV care to screen for cervical cancer in Ethiopia
A patient-centered program tests a simple HPV self-collection approach within HIV clinics in Ethiopia to help detect cervical cancer earlier.
-
HOPE-inG: Increasing cervical cancer screening for women with HIV in Ghana
A study tests a home-based HPV self-sampling approach plus a tailored communication plan to help women living with HIV in Ghana get screened more often for cervical cancer.
-
CODA-based cervical cancer screening for LMICs using CRISPR and fluorescence
A low-resource, rapid test called CODA uses CRISPR and light signals to detect cervical cancer markers in women in sub-Saharan Africa to improve screening.
-
CODA-based cervical cancer screening in low-resource settings
A new, quick, low-cost test using CRISPR and fluorescence readouts to help screen for cervical cancer in women in sub-Saharan Africa.
-
CATSystem: a digital tool to boost cervical cancer screening and follow-up in Kenya
A digital tracking system helps doctors and patients in Kenya improve cervical cancer screening, treatment referrals, and follow-up, especially for women living with HIV.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.