Investigating how antiretroviral therapy affects the risk of oral HPV infection in people with HIV
Official title: The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
Funded at Lsu Health Sciences Center · NIH-10893234 · Data updated 2026-11-12
This study is looking at how taking HIV medication might affect the risk of getting oral HPV in people living with HIV, and it will compare those on treatment to others who are HIV-negative, to help understand how these medications impact oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 16, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $637,738 |
| NIH project number | 1R01DE033878-01 |
| Project ID | NIH-10893234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals living with HIV who are undergoing antiretroviral therapy, as well as those taking ART for pre-exposure prophylaxis.
✕Less likely to help
Patients who are not on antiretroviral therapy or those who do not have any risk factors for HPV infection may not benefit from this research.
What this research studies
This research examines the relationship between antiretroviral therapy (ART) and the risk of oral human papillomavirus (HPV) infection in individuals living with HIV. It aims to understand how ART may impact the structural integrity of oral mucosal tissue, potentially increasing susceptibility to HPV. The study will compare the prevalence of oral HPV infection in people taking ART for HIV management and those taking it for pre-exposure prophylaxis (PrEP) against a control group of HIV-negative individuals. By analyzing oral mucosal samples, the research seeks to provide insights into the effects of ART on oral health in the context of HPV.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of oral HPV risks in individuals on antiretroviral therapy.
How similar studies have gone: While the specific approach of this research is novel, prior studies have indicated potential links between ART and increased HPV susceptibility, suggesting a need for further investigation.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Cameron, Jennifer Erin — Lsu Health Sciences Center
- Study coordinator: Cameron, Jennifer Erin
Related research
Other NIH-funded projects on the same topics.
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Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria
This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.
-
Antibodies and vaginal bacteria in HPV-related cervical changes
This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.
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Oral bacteria, gum disease, and oral HPV in people living with HIV
This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.
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How HIV Treatment Might Change Oral HPV Risk
A study explored how antiretroviral therapy for HIV could affect the mouth’s lining and the chance of catching oral HPV, with participants including people living with HIV on ART and people using ART for PrEP.
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Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients
This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.
-
Understanding how HIV medication affects oral HPV infection
This research explores if medications for HIV or HIV prevention might make people more likely to get oral human papillomavirus (HPV) infections.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.