Using a dietary supplement to prevent HPV infection persistence
Official title: A Pilot Study to Test the Effect of the Association of Epigallocatechin Gallate (EGCG), Folic Acid and Vitamin B12 in Preventing the Persistence of Human Papilloma Virus (HPV) Infection.
Run by Lo.Li.Pharma s.r.l · NCT06285357 · Data updated 2026-11-12
This study tests if a dietary supplement with EGCG, folic acid, and vitamin B12 can help people with cervical HPV infections avoid long-term problems that could lead to cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 25 Years to 65 Years |
| Sex | Women only |
| Enrollment | 100 (estimated) |
| Sponsor | Lo.Li.Pharma s.r.l Industry-sponsored |
| Locations | 1 site (Modena, Modena) |
| Status | Recruiting |
| Started | February 19, 2024 |
| Main results expected | March 2026 |
| Study ends | August 2026 |
| Registry record updated | November 20, 2025 |
| Trial ID | NCT06285357 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals who have tested positive for high-risk HPV DNA.
✕Probably not a fit
Patients who do not have high-grade squamous intraepithelial lesions (HSIL) may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of a dietary supplement containing epigallocatechin gallate (EGCG), folic acid, and vitamin B12 on patients with cervical HPV infections. The goal is to determine whether this combination can help prevent the persistence of HPV, which is known to lead to cervical cancer. Participants will be monitored for changes in HPV status following the intervention. The study aims to provide insights into alternative treatment options for HPV infections.
Why it matters
Potential benefit: If successful, this approach could offer a new preventive strategy against the persistence of HPV infections, potentially reducing the risk of cervical cancer.
How similar studies have gone: While there is ongoing research into dietary supplements for HPV treatment, this specific combination of EGCG, folic acid, and vitamin B12 is relatively novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * HR-HPV DNA test positivity Exclusion Criteria: * No HSIL
Where it's running
-
Azienda Ospedaliero-Universitaria di Modena
Modena, Modena, Italy Recruiting
Study contacts
- Study coordinator: Giovanni Grandi
- Email: giovanni.grandi@unimore.it
- Phone: +390594222830
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Risk of cervical cancer after HPV detection in healthy women
This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.
-
Dysplasix™ intravaginal suppositories for women with high‑risk HPV and mild cervical cell changes
This trial tests whether nightly Dysplasix™ vaginal suppositories can clear high‑risk HPV and help mild cervical cell changes (ASC‑US or LSIL) in adult women.
-
At-home HPV self-collection kits for cervical cancer screening
We are testing different ways to give at-home HPV self-collection kits to under-screened people aged 25–65 to see if more of them complete cervical cancer screening and follow-up.
-
Comparing clinic-only versus clinic plus community outreach to offer HPV self-collection for cervical screening in women with HIV
This project will test whether adding community health worker outreach to clinic services helps more women living with HIV complete HPV self-collection for cervical screening.
-
CHW4CervixHealth: HPV self-collection kits with community health workers
This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.
-
Q-Pad menstrual-pad test to detect high-risk HPV and cervical precancer
This study tests whether a home menstrual-pad kit (Q-Pad) can detect high-risk HPV and cervical precancer in people referred for colposcopy after an abnormal Pap or HPV result.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.