Understanding how HIV medication affects oral HPV infection
The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
This research explores if medications for HIV or HIV prevention might make people more likely to get oral human papillomavirus (HPV) infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11193516 on NIH RePORTER |
What this research studies
People living with HIV are at a higher risk for head and neck cancers caused by HPV, even when their HIV is well-managed with medication. Doctors have noticed that oral HPV infections and related problems might increase after starting HIV medication. This project aims to see if these medications could change the protective lining in the mouth, making it easier for HPV to take hold. We will compare oral HPV infection rates and examine mouth tissue in people taking HIV medication, those taking it for prevention, and individuals not on these medications.
Who could benefit from this research
Good fit: Ideal candidates for this research would include people living with HIV who are taking antiretroviral therapy, individuals taking ART for HIV pre-exposure prophylaxis (PrEP), and healthy individuals not taking these medications.
Not a fit: Patients not taking antiretroviral therapy for HIV treatment or prevention may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help us understand how to reduce the risk of oral HPV infection and related cancers for people taking HIV medications.
How similar studies have performed: Prior lab studies using artificial tissue models have suggested a link, but these findings have not yet been confirmed in clinical studies with real patient samples.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Cameron, Jennifer Erin — Lsu Health Sciences Center
- Study coordinator: Cameron, Jennifer Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.