Understanding how HIV medication affects oral HPV infection
Official title: The role of antiretroviral therapy in susceptibility to oral human papillomavirus (HPV) infection
Funded at Lsu Health Sciences Center · NIH-11193516 · Data updated 2026-11-12
This research explores if medications for HIV or HIV prevention might make people more likely to get oral human papillomavirus (HPV) infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | September 16, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $638,067 |
| NIH project number | 5R01DE033878-02 |
| Project ID | NIH-11193516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include people living with HIV who are taking antiretroviral therapy, individuals taking ART for HIV pre-exposure prophylaxis (PrEP), and healthy individuals not taking these medications.
✕Less likely to help
Patients not taking antiretroviral therapy for HIV treatment or prevention may not directly benefit from this specific research.
What this research studies
People living with HIV are at a higher risk for head and neck cancers caused by HPV, even when their HIV is well-managed with medication. Doctors have noticed that oral HPV infections and related problems might increase after starting HIV medication. This project aims to see if these medications could change the protective lining in the mouth, making it easier for HPV to take hold. We will compare oral HPV infection rates and examine mouth tissue in people taking HIV medication, those taking it for prevention, and individuals not on these medications.
Why it matters
Potential benefit: If successful, this work could help us understand how to reduce the risk of oral HPV infection and related cancers for people taking HIV medications.
How similar studies have gone: Prior lab studies using artificial tissue models have suggested a link, but these findings have not yet been confirmed in clinical studies with real patient samples.
Where this research is happening
-
Lsu Health Sciences Center
New Orleans, United States Active
Researchers
- Principal investigator: Cameron, Jennifer Erin — Lsu Health Sciences Center
- Study coordinator: Cameron, Jennifer Erin
Related research
Other NIH-funded projects on the same topics.
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Epigenetics of oral HPV-related mouth and throat cancer in people with HIV in Nigeria
This project looks for DNA markers in people living with HIV in Nigeria to find who has or might develop HPV-related mouth and throat cancers.
-
Antibodies and vaginal bacteria in HPV-related cervical changes
This project looks at whether antibodies bind different vaginal bacteria in women with HPV or cervical cell changes to understand why some women develop more serious lesions.
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Oral bacteria, gum disease, and oral HPV in people living with HIV
This project looks at how the mouth’s bacteria and gum disease relate to oral HPV in people with HIV, and what immune factors might be involved.
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How HIV Treatment Might Change Oral HPV Risk
A study explored how antiretroviral therapy for HIV could affect the mouth’s lining and the chance of catching oral HPV, with participants including people living with HIV on ART and people using ART for PrEP.
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Understanding how the penile cancer microbiome and p16 relate to HPV and outcomes across diverse patients
This project will look at how the tiny microbes living in penile tumors, p16 protein levels, high-risk HPV, and clinical outcomes are connected across patients from different regions.
-
Oral HPV-related mouth and throat cancer risk in people with HIV in Nigeria
This project looks for DNA changes in mouth samples that could help spot and predict HPV-related mouth and throat cancers in people living with HIV in Nigeria.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.