Estimating the prevalence of high-risk HPV infections in women and girls across multiple countries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to estimate the point-prevalence of high-risk HPV infections among girls and women aged 9-50 years across eight countries, including South Asian and sub-Saharan African nations. It will utilize cross-sectional surveys and longitudinal studies to gather data on HPV incidence and risk factors, with a focus on low socio-economic populations. The study will implement a harmonized protocol to ensure comparability of data, while also adapting to country-specific contexts. Qualitative sub-studies will explore gender-related dynamics affecting HPV burden and access to prevention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. 9 to 50 years old (for urban and rural CSSs) at the time of enrollment.
2. Resident in the selected community for at least the past 3 months (with the exception of pastoralists, refugees, and commercial sex workers).
3. Able to understand the purpose of the study and study procedures.
4. If aged 18 years or older or legally considered an emancipated minor, able and willing to provide consent to participate in the study including sample collection.
5. If aged \<18 years (and not considered an emancipated minor), supported in their participation by a parent or guardian who is able and willing to provide consent, and
6. If aged \<18 years (and not considered an emancipated minor), able and willing to provide assent to participate in the study.

Exclusion Criteria:

1. Decline consent to participate any activity of the study.
2. A medical condition or other reason, not directly related to HPV infection or HPV-related diseases, in the opinion of the investigator, precludes enrolment in the study.

Where it's running

• Institut National pour la Recherche Biomedicale (INRB)
  Kinshasa, Democratic Republic of the Congo Recruiting
• Diarrhoeal Disease Research, Bangladesh (icddr,b)
  Dhaka, Bangladesh Completed
• University of Health and Allied Sciences (UHAS)
  Ho, Volta Region, Ghana Completed
• Dhulikhel Hospital Kathmandu University Hospital (DHKUH)
  Dhulikhel, Nepal Completed
• Aga Khan University (AKU)
  Karachi, Pakistan Completed
• College of Medicine and Allied Health Sciences (COMAHS)
  Freetown, Sierra Leone Completed

Study contacts

• Principal investigator: Alexandra Hill — Associate Research Scientist
• Study coordinator: Julia Lynch
• Email: julia.lynch@ivi.int
• Phone: +8228811149

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Risk of cervical cancer after HPV detection in healthy women

  This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

  Recruiting Karolinska Institutet · Stockholm · NCT07850128

• Dysplasix™ intravaginal suppositories for women with high‑risk HPV and mild cervical cell changes

  This trial tests whether nightly Dysplasix™ vaginal suppositories can clear high‑risk HPV and help mild cervical cell changes (ASC‑US or LSIL) in adult women.

  Recruiting Phase 2 Amplexd Therapeutics, Inc. · Shatin, New Territories · NCT07572396

• At-home HPV self-collection kits for cervical cancer screening

  We are testing different ways to give at-home HPV self-collection kits to under-screened people aged 25–65 to see if more of them complete cervical cancer screening and follow-up.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07453459

• Comparing clinic-only versus clinic plus community outreach to offer HPV self-collection for cervical screening in women with HIV

  This project will test whether adding community health worker outreach to clinic services helps more women living with HIV complete HPV self-collection for cervical screening.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Kampala · NCT07428330

• CHW4CervixHealth: HPV self-collection kits with community health workers

  This project will test whether giving self-collection HPV kits during community workshops led by community health workers helps increase screening among under-screened women aged 25–65 and will first compare kit results to clinical Pap smears.

  Recruiting Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07336134

• Q-Pad menstrual-pad test to detect high-risk HPV and cervical precancer

  This study tests whether a home menstrual-pad kit (Q-Pad) can detect high-risk HPV and cervical precancer in people referred for colposcopy after an abnormal Pap or HPV result.

  Recruiting at 3 sites Qurasense · New Haven, Connecticut and 2 other locations · NCT07281599

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.